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TFAP4

  • Official Full Name

    transcription factor AP-4 (activating enhancer binding protein 4)

  • Overview

    Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed 2833704); Hu et al., 1990 (PubMed 2123466)).
  • Synonyms

    TFAP4; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP 4 (activating enhancer binding protein 4); transcription factor AP-4; AP 4; bHLHc41; activating enhancer-binding protein 4; class C basic helix-loop-helix protein 41; transcription factor AP-4 (activating enhancer-binding protein 4); AP-4;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFAP4-1137HCL Recombinant Human TFAP4 293 Cell Lysate HEK293 N/A
Human TFAP4-2177H-B Recombinant Human TFAP4 Protein Pre-coupled Magnetic Beads HEK293
Human TFAP4-2133HFL Recombinant Full Length Human TFAP4 Protein, C-Flag-tagged Mammalian cells Flag
Human TFAP4-2177H Recombinant Human TFAP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tfap4-6341M Recombinant Mouse Tfap4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TFAP4 involved in several pathways and played different roles in them. We selected most pathways TFAP4 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerWNT9B;WNT1;ELK1;WNT3A;PTCH1;FZD7;HSPG2;PXN;CAMK2A

TFAP4 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP4 itself. We selected most functions TFAP4 had, and list some proteins which have the same functions with TFAP4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSPHK1;RBPJB;SRY;FOXA1;ACD;TCF3;ZBTB7A;ZFY1;SP140L
E-box bindingARNTL2;TCF4;ATOH8;TCF21;MYOG;MYOD1;NEUROG1;BHLHE40;ARNTL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTXK;ESR1;ZNF331;ZNF253;NEUROD6;GATA1;ZFP639;HOXC11;NR2C1
histone deacetylase bindingKAT2A;TOP2A;RFXANK;MAGEA2;HDAC4;TRAF6;FOXP3;SFPQ;CAMTA2
protein bindingTMX3;DNAI1;TPR;UBE2F;HSPA1A;SYT16;BLOC1S5;MPRIP;RNF149
NOT protein heterodimerization activity
protein homodimerization activityEIF2AK1;THRA;NR6A1A;PRLR;RIPK2;CHMP1A;MID2;IL6R;SLIT2
sequence-specific DNA bindingHOXA9A;EMX3;PAX7A;SCAND2P;DHARMA;PGBD1;NR1H3;ERG;SFPI1
NOT transcription coactivator activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingCEBPA;ATF1;HIF1A;MYOD1;NKX2;MYF6;HNF1B;FOXC1;RFX1
transcription regulatory region DNA bindingZFP382;SP1;CALCOCO1;TP73;GABPB2;WNT5A;HIVEP3;HHEX;ZFHX3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNOBOX;GATA3;SIX1;YBX1;POU2F3;RAX;HMGA2;MEOX1;NDN

TFAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP4.

mdm2_human_probe; GOLGA2; TRAF1; EXOSC8; FBXW11; PRDM5; mdm2_human_gene; AIM2; Fbxw11; Cdkn2aip; Kctd5

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