Tfpi
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Official Full Name
Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
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Overview
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 Nm. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. -
Synonyms
TFPI; EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rabbit
- Rat
- Rhesus macaque
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Insect Cell
- Rabbit
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Tfpi Related Articles
- Tfpi Related Research Area
Tfpi involved in several pathways and played different roles in them. We selected most pathways Tfpi participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tfpi were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | SERPINA1D;C3AR1;SERPINA1;MASP1;Hc;C1QA;F13A1;SERPINC1;VWF |
Tfpi has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tfpi itself. We selected most functions Tfpi had, and list some proteins which have the same functions with Tfpi. You can find most of the proteins on our site.
Function | Related Protein |
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endopeptidase inhibitor activity | Serpina1b;AHSG;SPINK1;C3B.2;USP14;MUG1;CST7;UCHL5;SERPINF2 |
serine-type endopeptidase inhibitor activity | SERPINA1D;SPINK2;SPINK4;SERPINH2;OVST;SPINT4;A1i3;PCSK1NL;SERPINB1L3 |
Tfpi has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tfpi here. Most of them are supplied by our site. Hope this information will be useful for your research of Tfpi.
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- Q&As
- Reviews
Q&As (5)
Ask a questionMonitoring TFPI levels is crucial in patients with a history of thrombotic events, individuals at high risk of clotting disorders, and those undergoing anticoagulant therapy.
Research suggests that manipulating TFPI levels might be explored to reduce thrombotic complications in surgical and medical settings, potentially improving patient outcomes.
Manipulating TFPI levels may pose challenges, as it could potentially lead to bleeding disorders. Balancing the anticoagulant effects with the risk of bleeding is a critical consideration.
TFPI has anti-inflammatory effects by inhibiting the activation of immune cells and downregulating inflammatory mediators. This dual role makes it a potential therapeutic target in conditions involving both coagulation and inflammation.
Pharmaceutical research can explore the development of drugs that either enhance or mimic the activity of TFPI, providing new avenues for anticoagulant therapies.
Customer Reviews (3)
Write a reviewThis property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.
Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.
Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.
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