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Tfpi

  • Official Full Name

    Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

  • Overview

    Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 Nm. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
  • Synonyms

    TFPI; EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus macaque
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Insect Cell
  • Rabbit
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFPI-875H Active Recombinant Human TFPI protein, His-tagged HEK293 His Asp 29 - Lys 282
Human TFPI-106H Recombinant Human TFPI protein, His/GST-tagged E.coli His/GST Asp29~Met304
Human TFPI-107H Recombinant Human TFPI protein, His/GST-tagged E.coli His/GST Asp29~Cys251
Human TFPI-2333H Recombinant Human TFPI, His-tagged E.coli His 299aa
Human TFPI-105H Recombinant Human TFPI protein, His-tagged E.coli His Asp29~Glu210
Human TFPI-2746HCL Recombinant Human TFPI cell lysate Human Cell N/A
Human TFPI-646HB Recombinant Human TFPI protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp29-Lys282
Human TFPI-3565H Recombinant Human TFPI protein, GST-tagged E.coli GST 29-280aa
Human TFPI-751H Recombinant Human TFPI Protein, Biotinylated HEK293 304
Human TFPI-752H Recombinant Human TFPI Protein HEK293 304
Human TFPI-646H Recombinant Human TFPI protein, His-Avi-tagged HEK293 His-Avi Asp29-Lys282
Human TFPI-2145H Active Recombinant Human TFPI protein, His-tagged HEK293 His Met1-Lys282
Human TFPI-5798H Recombinant Human TFPI Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TFPI-707H Recombinant Human TFPI Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TFPI-1246H Recombinant Human TFPI Protein, His-tagged HEK293F N-His Asp29-Met304
Human TFPI-6424H Recombinant Human TFPI Protein (Asp29-Phe209), N-His tagged E.coli N-His Asp29-Phe209
Human TFPI-876H Recombinant Human TFPI protein, His-tagged, Biotinylated HEK293 His Asp 29 - Lys 282
Mouse Tfpi-874M Recombinant Mouse Tfpi, His tagged Human Cell His
Mouse Tfpi-574M Recombinant Mouse Tfpi Protein, His-tagged E.coli His Leu29~Asn306
Mouse Tfpi-981M Active Recombinant Mouse Tfpi protein(Met1-Lys289), His-tagged HEK293 C-His Met1-Lys289
Mouse TFPI-2843MCL Recombinant Mouse TFPI cell lysate Human Cell N/A
Mouse CAB11612RM Rabbit Monoclonal Antibody to Mouse Tissue Factor Pathway Inhibitor Rabbit N/A
Mouse Tfpi-6383M Recombinant Mouse Tfpi Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tfpi-9155M Recombinant Mouse Tfpi Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tfpi-9155M-B Recombinant Mouse Tfpi Protein Pre-coupled Magnetic Beads HEK293
Mouse CAB11613RM Rabbit Monoclonal Antibody to Mouse Tissue Factor Pathway Inhibitor Rabbit N/A
Rat Tfpi-575R Recombinant Rat Tfpi Protein, His-tagged E.coli His Leu29~His302
Rabbit TFPI-576R Recombinant Rabbit TFPI Protein, His/GST-tagged E.coli His/GST Lys39~Gly275
Rabbit TFPI-5528R Recombinant Rabbit TFPI protein, His-tagged Yeast His 25-300a
Rabbit TFPI-2260R Recombinant Rabbit TFPI protein, His-tagged Insect Cell His 25-300aa
Rabbit TFPI-3566R Recombinant Rabbit TFPI protein, His-tagged E.coli His 25-300a
Rabbit TFPI-5070R Recombinant Rabbit TFPI protein, His-tagged HEK293 His 25-300aa
Rhesus macaque TFPI-4683R Recombinant Rhesus macaque TFPI protein, His-tagged HEK293 His 254
Rhesus macaque TFPI-753R Recombinant Rhesus macaque TFPI Protein HEK293 304
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tfpi Related Articles
  • Tfpi Related Research Area

Tfpi involved in several pathways and played different roles in them. We selected most pathways Tfpi participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tfpi were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSERPINA1D;C3AR1;SERPINA1;MASP1;Hc;C1QA;F13A1;SERPINC1;VWF

Tfpi has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tfpi itself. We selected most functions Tfpi had, and list some proteins which have the same functions with Tfpi. You can find most of the proteins on our site.

Function Related Protein
endopeptidase inhibitor activitySerpina1b;AHSG;SPINK1;C3B.2;USP14;MUG1;CST7;UCHL5;SERPINF2
serine-type endopeptidase inhibitor activitySERPINA1D;SPINK2;SPINK4;SERPINH2;OVST;SPINT4;A1i3;PCSK1NL;SERPINB1L3

Tfpi has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tfpi here. Most of them are supplied by our site. Hope this information will be useful for your research of Tfpi.

ssrna_ug

Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
Franchini, M; et al. Next-generation treatment of acquired hemophilia A. EXPERT OPINION ON ORPHAN DRUGS 3:245-251(2015).
  • Q&As
  • Reviews

Q&As (5)

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In which medical scenarios is monitoring TFPI protein particularly crucial? 06/20/2022

Monitoring TFPI levels is crucial in patients with a history of thrombotic events, individuals at high risk of clotting disorders, and those undergoing anticoagulant therapy.

Can TFPI protein be explored in the context of preventing complications in surgery or other medical procedures? 01/23/2022

Research suggests that manipulating TFPI levels might be explored to reduce thrombotic complications in surgical and medical settings, potentially improving patient outcomes.

Are there any challenges or risks associated with manipulating TFPI levels for therapeutic purposes? 07/27/2019

Manipulating TFPI levels may pose challenges, as it could potentially lead to bleeding disorders. Balancing the anticoagulant effects with the risk of bleeding is a critical consideration.

How does TFPI contribute to the regulation of inflammation in addition to its anticoagulant properties? 03/11/2017

TFPI has anti-inflammatory effects by inhibiting the activation of immune cells and downregulating inflammatory mediators. This dual role makes it a potential therapeutic target in conditions involving both coagulation and inflammation.

In what ways can TFPI protein be a target for drug development in the pharmaceutical industry? 04/22/2016

Pharmaceutical research can explore the development of drugs that either enhance or mimic the activity of TFPI, providing new avenues for anticoagulant therapies.

Customer Reviews (3)

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Reviews
03/04/2022

    This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.

    05/31/2020

      Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.

      07/22/2016

        Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.

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