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THBS2

  • Official Full Name

    thrombospondin 2

  • Overview

    The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
  • Synonyms

    THBS2; thrombospondin 2; TSP2; thrombospondin-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human THBS2-101H Active Recombinant Human THBS2, His-tagged Mammalian cells His
Human THBS2-8253H Recombinant Human THBS2 protein, His & T7-tagged E.coli His/T7 Asp968~Ile1172 (Accession # P35442)
Human THBS2-1100HCL Recombinant Human THBS2 293 Cell Lysate HEK293 N/A
Human THBS2-4183H Recombinant Human THBS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human THBS2-6444H Recombinant Human THBS2 Protein (Asp968-Ile1172), N-His tagged E.coli N-His Asp968-Ile1172
Human THBS2-3269H Recombinant Human THBS2 protein, His-tagged E.coli His 19-100 aa
Human THBS2-4183H-B Recombinant Human THBS2 Protein Pre-coupled Magnetic Beads HEK293
Human THBS2-0790H Active Recombinant Human THBS2 protein, His-tagged HEK293 His Gly19-Ile1172
Mouse THBS2-16737M Recombinant Mouse THBS2 Protein Mammalian Cell His
Mouse Thbs2-8254M Recombinant Mouse Thbs2 protein, His & GST-tagged E.coli His/GST Asp968~Arg1170 (Accession # Q03350)
Mouse THBS2-9182M Recombinant Mouse THBS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse THBS2-9182M-B Recombinant Mouse THBS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse THBS2-830M Recombinant Mouse THBS2 Protein (19-232 aa), His-tagged E.coli His 19-232 aa
Mouse THBS2-1539M Recombinant Mouse THBS2 Protein (19-232 aa), His-tagged Yeast His 19-232 aa
Rat Thbs2-1770R Recombinant Rat Thbs2 protein, His & GST-tagged E.coli His/GST Asp968~Arg1170
Chicken THBS2-1151C Recombinant Chicken THBS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • THBS2 Related Articles
  • THBS2 Related Research Area
  • THBS2 Related Signal Pathway

THBS2 involved in several pathways and played different roles in them. We selected most pathways THBS2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeSFTPD;HLA-DRB5;HLA-E;BF2;BF1;STX7;ITGB2L;TLR2-2;ATP6AP1
PIK-Akt signaling pathwayHGF;ITGB5;PPP2R5B;HRAS;PPP2CB;TNN;FGF5;FGF3;PPP2R3C
Focal adhesionIBSP;MYLPFA;RHOAD;KDRL;ITGA4;MYL12.1;GRB2;PAK3;PRKCBB
ECM-receptor interactionTHBS4B;LAMA4;VTNB;ITGA6B;COL2A1B;FN1;COL4A5;ITGAV;TNXB
MalariaCSF3;ICAM1;IL12A;MYD88;HBA-A2;CCL2;KLRB1;Ccl12;CD36

THBS2 has several biochemical functions, for example, calcium ion binding, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS2 itself. We selected most functions THBS2 had, and list some proteins which have the same functions with THBS2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingKCNIP3A;MMP8;EFCAB7;CDH2;CALR3B;ATP2A2;CDH9;PON1;EFCAB3
heparin bindingCXCL11;F11;FGFR1A;APOA5;FGFBP3;HBEGF;RSPO3;CXCL13;UBE4A
protein bindingEWSR1A;NARG1;SLC30A3;RNF135;C10orf119;NOLC1;ARMCX5;RCBTB2;CDKAL1

THBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS2.

Cacna2d1

Lin, D; Alborn, WE; et al. Comparison of Protein Immunoprecipitation-Multiple Reaction Monitoring with ELISA for Assay of Biomarker Candidates in Plasma. JOURNAL OF PROTEOME RESEARCH 12:5996-6003(2013).
Czekierdowski, A; Czekierdowska, S; et al. MICROVESSEL DENSITY AND CPG ISLAND METHYLATION OF THBS2 GENE IN MALIGNANT OVARIAN TUMORS. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 59:53-65(2008).
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