thbs4
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  • Official Full Name
  • thrombospondin 4
  • Background
  • The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.
  • Synonyms
  • THBS4; thrombospondin 4; thrombospondin-4; TSP4
Cat.#:THBS4-507HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Thrombospondin 4, His-tagged
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Cat.#:THBS4-114HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS4 protein, T7/His-tagged
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Cat.#:THBS4-121HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human THBS4, GST-tagged
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Cat.#:THBS4-8256HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THBS4 protein, His & GST-tagged
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Cat.#:Thbs4-120MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Thbs4, His-tagged
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Cat.#:Thbs4-8257MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Thbs4 protein, His & GST-tagged
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Cat.#:Thbs4-8258RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Thbs4 protein, His & GST-tagged
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Cat.#:THBS4-1774HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human THBS4 cell lysate
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Involved Pathway

THBS4 involved in several pathways and played different roles in them. We selected most pathways THBS4 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
TUBA8; ATP6V1G1; CTSLA; FCGR2A; CTSSB.2; ITGB1B.2; H2-AB1; FCGR2C; HLA-DMB; FCAR
PIK-Akt signaling pathway
RPS6KB1; DDIT4; ITGB7; PIK3R5; PPP2R2B; Ifna11; FGF13; SOS1; IL3; CREB3L2
Focal adhesion
SEPP1; ARHGAP35; COL27A1; THBS3; PAK6; ACTB; BIRC2; COL4A6; MYL12.1; IGF1RB
ECM-receptor interaction
COL1A1A; Npnt; ITGA10; COL11A2; THBS1; LAMC1; FN1A; COL6A5; IBSP; COL6A6
Malaria
CD36; TGFB1; IFNG; THBS3; GYPC; ICAM1; THBS4; IL1B; KLRC4-KLRK1; THBS2

Protein Function

THBS4 has several biochemical functions, for example, calcium ion binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS4 itself. We selected most functions THBS4 had, and list some proteins which have the same functions with THBS4. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein FSTL1A; ANXA8; NCL; SYTL2; PCDH2G17; PLA2G1B; PLA2G2D; MYL7; PLSCR1; NKD2
Function growth factor activity
Related Protein NRG3; IL9; VEGFAA; FGF11A; FGF13; IGF2; Artn; GRN; FGF16; MDKB
Function heparin binding
Related Protein COL5A1; ADAMTS3; ABP1; GM4980; FGFR2; SMOC2; APLP1; FGF7; PLA2G2D; LRPAP1
Function integrin binding
Related Protein COL16A1; TSPAN4; CTGF; FN1; TLN1; LYN; TIMP2; LAMB1; ICAM4; WISP3
Function protein binding
Related Protein SSU72; SPAST; RAB7L1; HTR6; ITCH; COPB1; TLR3; HER5; LAPTM5; DNMBP

Interacting Protein

THBS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS4.
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