TXNIP
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Official Full Name
thioredoxin interacting protein
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Overview
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. -
Synonyms
TXNIP; thioredoxin interacting protein; THIF; VDUP1; HHCPA78; EST01027; thioredoxin-interacting protein; thioredoxin binding protein 2; thioredoxin-binding protein 2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- B2M
- SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TXNIP involved in several pathways and played different roles in them. We selected most pathways TXNIP participated on our site, such as Immune System, Inflammasomes, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TXNIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | PAG1;SIGIRR;TIRAP;ASB11;TRIM10;IFITM3;KIF22;FBXO44;SIGLEC5 |
| Inflammasomes | PANX1;TXNIP;BTR06;SUGT1;BTR30;TXN;BTR29;TXNIPA;BTR22 |
| Innate Immune System | CLEC5A;DEFB106A;AGER;POLR3GLA;CTS7;TREX1;BTR22;Txn1;BTR06 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | CYLD;BTR29;SUGT1;BTR18;NLRP3;BTR22;BTR16;BTR09;BTR12 |
| The NLRP3 inflammasome | BTR06;BTR12;BTR30;BTR22;SUGT1;TXNIPB;BTR18;TXNIPA;PANX1A |
TXNIP has several biochemical functions, for example, enzyme inhibitor activity, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TXNIP itself. We selected most functions TXNIP had, and list some proteins which have the same functions with TXNIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme inhibitor activity | UGT1A9;ANGPTL3;UGT1A1;ATPIF1A;SLN;PDE6G;CALU;GCHFR;PLN |
| protein binding | HECTD3;DSCAM;LRP12;HSFY1;WDR4;ELMO3;Fert2;MAGEA4;CCPG1 |
| ubiquitin protein ligase binding | PCBP2;ABI2;SCAMP3;TMBIM6;JAK1;UBE2R2;AXIN2;MAP1LC3C;CUL3B |
TXNIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TXNIP here. Most of them are supplied by our site. Hope this information will be useful for your research of TXNIP.
TXN; FHL1; deoB; ypeB; clpB; glpC; SMURF2; RGMA
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