THRA
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Official Full Name
thyroid hormone receptor, alpha
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Overview
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
THRA; thyroid hormone receptor, alpha; ERBA1, THRA1, THRA2, thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v erb a) oncogene homolog) , thyroid hormone receptor, alpha (erythroblastic leukemia viral (v erb a) oncogene homolog, avian); thyroid hormone receptor alpha; AR7; EAR 7.1/EAR 7.2; ERBA; NR1A1; THRA3; c erbA 1; C erbA alpha; EAR7; ERBA1; Thyroid hormone receptor alpha 2; TR alpha 2; EAR-7; c-erbA-alpha; ERBA-related 7; OTTHUMP00000164469; OTTHUMP00000164470; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroi; THRA1; THRA2; ERB-T-1; c-ERBA-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- DDK
- GST
- His
- His (Fc)
- Avi
- B2M
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
THRA involved in several pathways and played different roles in them. We selected most pathways THRA participated on our site, such as Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with THRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | NPY8BR;PTGER1B;RXFP3;TAAR64;NTSR2;VIPR1B;EDNRAA;TAAR6;TAAR2 |
| Thyroid hormone signaling pathway | MED24;KRAS;SRC;PRKACG;MED13L;PIK3CA;PRKCG;TRP53;NOTCH4 |
THRA has several biochemical functions, for example, TBP-class protein binding, chromatin DNA binding, intronic transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THRA itself. We selected most functions THRA had, and list some proteins which have the same functions with THRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TBP-class protein binding | TAF1B;PSMC3;HHEX;PSMC4;BRF1A;BRF1B;EFCAB11;PSMC1;DR1 |
| chromatin DNA binding | PRDM14;FOXC2;THRB;FOXO3;HIST1H1C;EP300;NEUROG3;HIST1H1A;ZIC2 |
| intronic transcription regulatory region DNA binding | NKX2-1;THRA |
| protein binding | BTF3;THOP1;DUSP21;FOXR2;LTBR;FMNL1;PHLPP1;RAB8B;NCF4 |
| protein complex binding | IST1;ERCC8;RIPK1;AP2B1;BAX;CDK5RAP1;FYB;TAB1;MAPK8IP2 |
| protein domain specific binding | HOXB1;RUNX2;CBX3;COX4I2;CACNB2;MRPS31;TACC3;STX1B;ETV6 |
| protein heterodimerization activity | BCL2L10;ARNT;ADD2;SNX1;CYBA;SOX5;SCUBE1;SNX2;SOX17 |
| protein homodimerization activity | IL6R;PRDM6;IRF3;DMRTB1;JAM3;PCYT1A;ENPP1;GLA;RAB11FIP2 |
| sequence-specific DNA binding | LHX2;SREBF1;HMX2;GRHL3;FOXO1A;MSX2;DLX5A;MAFGB;LHX2B |
| steroid hormone receptor activity | NR5A5;ESRRG;RORCB;OR51E2;RORC;NR5A1;NR1D2;NR1D4A;RXRAA |
| steroid receptor RNA activator RNA binding | |
| thyroid hormone binding | THRA;CTSH;ALDH1A3;CRYM;THRB |
| thyroid hormone receptor activity | NR1D4B;NR1D2A;NR1D4A;NR2F6;THRAA;NR1I3;BRD8;NR4A3;THRA |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | PTH;NR5A2;TEAD2;MEF2C;CREB1;JUN;SOX7;NR5A1;AHR |
| transcription factor activity, sequence-specific DNA binding | FOXP4;ZNF75D;EGR2A;POU3F3A;PAX3;TRP53;SIX2;E4F1;ZNF821 |
| transcription factor binding | TRIM6;JUNB;LEF1;ZFPM1;POU5F1;NKX3;TMEM173;PPRC1;PIANP |
| transcription regulatory region DNA binding | FOS;PPARG;ZNF649;ZFP821;SOX5;CARM1;RFX3;RREB1;NCOR1 |
| zinc ion binding | ADAM20;SEC24A;CA13;TRAF4A;GCH2;RNF111;NR4A2;MAP3K1;RC3H1 |
THRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THRA here. Most of them are supplied by our site. Hope this information will be useful for your research of THRA.
MED1; L3MBTL3; AMOTL2; Ncoa6; PKM; UBA1; UBE2N; AKAP13; UBE2V1; TXNRD1; CLIC1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of the THRA protein can be modulated by drugs or other small molecule compounds to treat diseases related to the THRA protein. For example, some drugs can inhibit the activity of the THRA protein to treat diseases such as hyperthyroidism.
The THRA protein has some association with other hormones or signaling molecules. For example, it can interact with other hormones such as glucocorticoids and sex hormones to co-regulate the expression of target genes. In addition, it can interact with other signaling molecules, such as the MAPK signaling pathway.
Some studies have shown that abnormal expression of THRA protein may be related to the occurrence and progression of some diseases, such as thyroid disease, autoimmune diseases, etc. In addition, THRA proteins may also be drug targets for the treatment of these diseases.
Biological significance of THRA protein in the human body is to regulate the physiological function of thyroid hormones. It can mediate its signal transduction through binding to thyroid hormones to maintain the body's metabolic balance and growth and development.
Interaction between THRA proteins and other nuclear receptors or proteins is complex. For example, it can interact with other thyroid hormone receptors (THRB and THRG) to form heterodimers that co-regulate the expression of target genes. In addition, it can interact with regulatory factors, affecting their activity.
Activity of THRA protein is regulated by a variety of factors, including the concentration of ligands (thyroid hormones), phosphorylation modifications, small molecule regulators, etc. These factors can affect the DNA binding capacity, transcriptional activation and ligand binding capacity of THRA proteins, thereby regulating their activity.
Customer Reviews (3)
Write a reviewThe stability of THRA is highly appreciated, and its ability to maintain stable properties even after multiple freeze-thaw cycles is very valuable in practical applications.
The short half-life and high clearance of THRA make it a promising candidate for new generation of therapeutic drugs.
This production process of THRA is truly green and environmentally friendly, with little impact on the environment.
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