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TIMM8A

Official Full Name

translocase of inner mitochondrial membrane 8 homolog A
Overview

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

TIMM8A; translocase of inner mitochondrial membrane 8 homolog A (yeast); DFN1, translocase of inner mitochondrial membrane 8 (yeast) homolog A; mitochondrial import inner membrane translocase subunit Tim8 A; DDP; MTS; deafness/dystonia peptide; deafness;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TIMM8A-2486H	Recombinant human TIMM8A, His-tagged	E.coli	His		Inquiry
Human	TIMM8A-3239H	Recombinant Human TIMM8A, GST-tagged	E.coli	GST	1-97aa	$319 / 25ug
Human	TIMM8A-1065HCL	Recombinant Human TIMM8A 293 Cell Lysate	HEK293	N/A		Inquiry
Rhesus Macaque	TIMM8A-4720R	Recombinant Rhesus monkey TIMM8A Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TIMM8A-4534R	Recombinant Rhesus Macaque TIMM8A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TIMM8A-4534R-B	Recombinant Rhesus Macaque TIMM8A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TIMM8A-1059Z	Recombinant Zebrafish TIMM8A	Mammalian Cell	His		Inquiry
Chicken	TIMM8A-5603C	Recombinant Chicken TIMM8A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TIMM8A Related Articles

TIMM8A involved in several pathways and played different roles in them. We selected most pathways TIMM8A participated on our site, such as Metabolism of proteins, Mitochondrial protein import, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMM8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	EEF1B2;LTF;TBCB;ZNF408;EEF1A2;DNAJC19;SAE1;LMCD1;ARSK
Mitochondrial protein import	GFER;TIMM9;TIMM44;DNAJC19;TOMM6;MTX2;SLC25A13;CHCHD4;GRPEL1

TIMM8A has several biochemical functions, for example, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMM8A itself. We selected most functions TIMM8A had, and list some proteins which have the same functions with TIMM8A. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	CLCA5;SMAD2;ATP2B2;ARFGAP3;RARAB;CYP2AA6;GMEB2;ZNF454;ACAP3
protein binding	UBE2L3;POLR2C;SLC25A23;CCNB3;AKAP9;PPP4R4;SPA17;ACTN4;MAP4

TIMM8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMM8A here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMM8A.

STAM2; KRT15; env; JOSD1; ADRM1; USP30; TIMM13; XRCC3; CDT1; TIMMDC1

Kojovic, M; Parees, I; et al. The syndrome of deafness-dystonia: Clinical and genetic heterogeneity. MOVEMENT DISORDERS 28:795-803(2013).

Mohiuddin, MS; Abbott, JK; et al. Diagnosis and evaluation of primary panhypogammaglobulinemia: A molecular and genetic challenge. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 131:1717-+(2013).