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TINF2

Official Full Name

TERF1 (TRF1)-interacting nuclear factor 2
Overview

This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
Synonyms

TINF2; TERF1 (TRF1)-interacting nuclear factor 2; TIN2; DKCA3; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TINF2-1060HCL	Recombinant Human TINF2 293 Cell Lysate	HEK293	N/A		Inquiry
Zebrafish	TINF2-4976Z	Recombinant Zebrafish TINF2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TINF2 involved in several pathways and played different roles in them. We selected most pathways TINF2 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TINF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	CENPE;CDT1;CEP78;RAD21;SGOL2;YWHAG1;BORA;TTK;CLASP1A
Cellular Senescence	RNF2;HMGA1;TERF2;CBX8;ERF;PHC1;HIST1H1C;HMGA1-RS1;PHC2
Cellular responses to stress	TXN2;CDKN2B;AGO1;SUZ12B;HMGA1-RS1;NUPL2;AMBRA1B;EPAS1B;MINK1
Chromosome Maintenance	CENPK;RUVBL2;MLF1IP;CENPW;MIS18BP1;TERF1;TINF2;CENPH;MIS18A
DNA Damage/Telomere Stress Induced Senescence	HIRA;HMGA1;HIST1H1C;H1F0;HIST1H1D;POT1;TERF1;UBN1;HIST1H1A
Meiosis	TEX12;SPO11;POT1;TERF2;SYCE1;DMC1;STAG2;TEX15;SUN1
Meiotic synapsis	STAG1;TERF2IP;SUN1;SYCE1;POT1;TINF2;TERF1;FKBP6;SYCP2
Packaging Of Telomere Ends	TERF1;TINF2;TERF2;POT1A;POT1;ACD

TINF2 has several biochemical functions, for example, NOT DNA binding, protein binding, telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TINF2 itself. We selected most functions TINF2 had, and list some proteins which have the same functions with TINF2. You can find most of the proteins on our site.

Function	Related Protein
NOT DNA binding	MBD5;XRCC4;SKIL;TINF2;HIPK2;NFIB
protein binding	SH2B1;FEM1B;PKM;TMEM64;EPO;TRAF7;SNRPE;HSCB;DSG1A
telomeric DNA binding	PIF1;TP53BP1;TERT;NCL;SMG6;TERFA;POT1A;CTC1;HNRNPD

TINF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TINF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TINF2.

TERF1; ACD; TERF2