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Tle4

Official Full Name

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
Overview

TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES.
Synonyms

TLE4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); ESG; BCE1; ESG4; GRG4; BCE-1; E(spI);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TLE4-3251H	Recombinant Human TLE4, GST-tagged	E.coli	GST	173-243aa	$319 / 25ug
Human	TLE4-1785HCL	Recombinant Human TLE4 cell lysate		N/A		Inquiry
Human	TLE4-938H	Recombinant Human TLE4 protein, His-tagged	E.coli	His	173-243 aa	$319 / 25ug
Mouse	TLE4-16815M	Recombinant Mouse TLE4 Protein	Mammalian Cell	His		Inquiry
Mouse	TLE4-9233M	Recombinant Mouse TLE4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TLE4-9233M-B	Recombinant Mouse TLE4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	TLE4-5810C	Recombinant Chicken TLE4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

Tle4 involved in several pathways and played different roles in them. We selected most pathways Tle4 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tle4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	SOX13;BCL9;TLE2;SOX32;RBBP5;TLE3;SRY;PYGO2;SOX4A
Degradation of beta-catenin by the destruction complex	CTBP2;TLE1;TLE2;TLE3B;TLE3;CTBP1;AES;TLE4;FAM123B
Formation of the beta-catenin:TCF transactivating complex	CDC73;TLE1;BCL9;BCL9L;LEO1;PYGO2;RBBP5;PYGO1;SMARCA4
NOTCH1 Intracellular Domain Regulates Transcription	HEYL;TLE4;TLE3;HEY1;HEY2;TLE2;TLE1;TUBB3
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	ZCCHC12;CYR61;TLE2;CDX4;TLE4;TCF4;HBP1;MYOG;CBY1
Repression of WNT target genes	AES;TLE3B;TLE4;TLE2;TLE3
Signal Transduction	UTS2D;NEDD8;STARD13;HECW1;RIT1;SOX32;RDH14A;SOX9B;DNAL4
Signaling by NOTCH	MDKB;DLK1;DNER;HEYL;MDK;RAB6A;TLE4;TLE3;DTX2

Tle4 has several biochemical functions, for example, chromatin binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tle4 itself. We selected most functions Tle4 had, and list some proteins which have the same functions with Tle4. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	CRTC2;GLI1;ANKRD2;RNF2;NCOA1;POU1F1;NAP1L2;LOXL2;SOX9A
molecular_function	FMNL1;OCLNB;MSTO1;MXRA8B;ARGLU1B;TMCO3;ODF2L;CSN3;BOLA2
protein binding	RASSF9;AHCYL1;OXA1L;ACVRL1;ZNF212;PCK2;PLEKHG2;RGS16;MED29
repressing transcription factor binding	EIF4E;TCF3;ARNTL;HDAC7A;KAT5;MAGEA2;MAGEA2B;CTNNB1;DDX20
transcription corepressor activity	ALX1;NR0B1;ZHX3;NCOR1;RYBP;ZBTB32;WWTR1;PFDN5;MAP3K10
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	ZFHX3;GATA6;POU3F3;CIR1;USF1;CEBPB;ATF2;ATF1;PDX1

Tle4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tle4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tle4.

brnQ3; mfd; tcaC1