tlr7
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  • Official Full Name
  • toll-like receptor 7
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
  • Synonyms
  • TLR7; toll-like receptor 7
Cat.#:TLR7-834MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TLR7 Protein (27-348 aa), GST-tagged
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Cat.#:TLR7-3260HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR7, His-tagged
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Cat.#:TLR7-903HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR7 protein, His-tagged
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Cat.#:TLR7-16829MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TLR7 Protein
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Cat.#:Tlr7-2005MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr7 protein, His & T7-tagged
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Cat.#:TLR7-1679RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR7 Protein
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Cat.#:TLR7-1680RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR7 Protein, hIgG1-tagged
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Cat.#:TLR7-1681RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR7 Protein, hIgG4-tagged
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Cat.#:TLR7-4736RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR7 Protein, His-tagged
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Cat.#:TLR7-1880CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLR7
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Cat.#:TLR7-1043HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TLR7 293 Cell Lysate
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Involved Pathway

TLR7 involved in several pathways and played different roles in them. We selected most pathways TLR7 participated on our site, such as Toll-like receptor signaling pathway, Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
TLR2-1; TLR8; IRAK1; CCL4L2; MAPK3; SPP1; Ifna15; FADD; CCL5; MAPK14A
Measles
IRF3; MSN; NFKBIB; TLR9; NFKBIA; HSPA1L; CCND3; FAS; CD209C; FCGR2B
Influenza A
DDX58; HLA-DRA; HLA-DRB5; NUP98; NFKBIA; IFNG; IFNA17; SOCS3; PRKCA; IL18

Protein Function

TLR7 has several biochemical functions, for example, double-stranded RNA binding, drug binding, siRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR7 itself. We selected most functions TLR7 had, and list some proteins which have the same functions with TLR7. You can find most of the proteins on our site.
Function
Related Protein
Function double-stranded RNA binding
Related Protein DHX15; OASL2; IFIH1; RNASEN; ELAVL1; HSP90AB1; TLR7; AGO1; YRDC; LRRFIP1
Function drug binding
Related Protein ACE; GABRA1; FOLR1; DHODH; ADH1; PPP3CA; ATP5O; PDE2A; HMGCS1; P2RX4
Function siRNA binding
Related Protein TARBP2; TLR7; TLR9; DICER1; MECP2; AGO2
Function single-stranded RNA binding
Related Protein HNRNPF; TLR7; A1CF; LUZP4; DDX58; STRBP; IFIT5; NXF1; LONP1; AGO2
Function transmembrane signaling receptor activity
Related Protein FZD7B; OR4N4; TLR2; GPR182; OR4C13; GP1BB; KLRB1; BCAM; CD300C; CD5

Interacting Protein

TLR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR7.
a8k1f4_human; MLF1; PSMD2; Hacd3; AARSD1; q7ard3_yerpe; GRAMD1A; MYD88

TLR7 Related Articles

Goff, PH; Hayashi, T; et al. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses. JOURNAL OF VIROLOGY 89:3221-3235(2015).
Rommler, F; Hammel, M; et al. Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7-and TLR9-Mediated Immune Responses of Human Immune Cells. PLOS ONE 10:-(2015).