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TLR7

  • Official Full Name

    toll-like receptor 7

  • Overview

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
  • Synonyms

    TLR7; toll-like receptor 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Macaca Mulatta (Rhesus Monkey)
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • hIgG1
  • hIgG4
  • His
  • MYC
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR7-903H Recombinant Human TLR7 protein, His-tagged E.coli His Pro887~Asp1036
Human TLR7-3260H Recombinant Human TLR7, His-tagged E.coli His 24-348aa
Human TLR7-1043HCL Recombinant Human TLR7 293 Cell Lysate HEK293 N/A
Human TLR7-3953H Active Recombinant Human TLR7 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human TLR7-3590H Recombinant Human TLR7 protein, His&Myc-tagged E.coli His&Myc 861-1049aa
Human TLR7-5895H Recombinant Human TLR7 Protein (Leu24-Ser348), N-His tagged E.coli N-His Leu24-Ser348
Mouse TLR7-16829M Recombinant Mouse TLR7 Protein Mammalian Cell His
Mouse Tlr7-2005M Recombinant Mouse Tlr7 protein, His & T7-tagged E.coli His/T7 Ser890~Asp1037 (Accession # P58681)
Mouse TLR7-834M Recombinant Mouse TLR7 Protein (27-348 aa), GST-tagged E.coli GST 27-348 aa
Mouse Tlr7-835M Recombinant Mouse Tlr7 protein, His & MYC-tagged E. coli His & MYC 27-348aa
Mouse Tlr7-836M Recombinant Mouse Tlr7 Protein, His-tagged E. coli His
Mouse TLR7-9238M Recombinant Mouse TLR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tlr7-5072M Recombinant Mouse Tlr7 protein, His&Myc-tagged HEK293 His&Myc 27-348aa
Mouse TLR7-9238M-B Recombinant Mouse TLR7 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey TLR7-1679R Recombinant Rhesus Monkey TLR7 Protein HEK293 N/A
Rhesus monkey TLR7-1681R Recombinant Rhesus Monkey TLR7 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey TLR7-1680R Recombinant Rhesus Monkey TLR7 Protein, hIgG1-tagged HEK293 hIgG1
Macaca Mulatta (Rhesus Monkey) TLR7-01H Recombinant Rhesus Monkey TLR7 Protein, His-tagged E.coli His 822
Rhesus Macaque TLR7-4736R Recombinant Rhesus monkey TLR7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR7-4550R Recombinant Rhesus Macaque TLR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR7-4550R-B Recombinant Rhesus Macaque TLR7 Protein Pre-coupled Magnetic Beads HEK293
Chicken TLR7-1880C Recombinant Chicken TLR7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLR7 Related Articles
  • TLR7 Related Research Area

TLR7 involved in several pathways and played different roles in them. We selected most pathways TLR7 participated on our site, such as Toll-like receptor signaling pathway, Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayMAP2K2B;IFNB1;TLR4BA;LY96;IFNAR2;IL6;IL-8;MAPK8;CD80
MeaslesPIK3R3;CD209A;CBLB;IL1A;CD46;IL2RA;TRAF6;CCND3;IFNA2
Influenza APRKCA;PYCARD;MAP2K1;CCL5;PIK3CG;IL18;XPO1;OAS3;MAP2K6

TLR7 has several biochemical functions, for example, double-stranded RNA binding, drug binding, siRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR7 itself. We selected most functions TLR7 had, and list some proteins which have the same functions with TLR7. You can find most of the proteins on our site.

Function Related Protein
double-stranded RNA bindingOASL1;DHX36;PRKRIP1;HSPD1;RNASEN;DDX58;ADARB1;YRDC;DGCR8
drug bindingMTOR;ADH1;DHODH;Alb;CHRNB4;CHKA;TOP2A;NR1I2;CYP2D6
siRNA bindingDICER1;MECP2;TLR9;TLR7;TARBP2;AGO2
single-stranded RNA bindingLSM14A;TLR8;LONP1;HMGB1;EIF2C3;DDX58;ANXA1;POLR2G;A1CF
transmembrane signaling receptor activityGPR124;OR6K3;CALCRLA;KLRB1;CD3D;DCC;VIPR1B;EVI2A;RYK

TLR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR7.

a8k1f4_human; MLF1; PSMD2; Hacd3; AARSD1; q7ard3_yerpe; GRAMD1A; MYD88

Goff, PH; Hayashi, T; et al. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses. JOURNAL OF VIROLOGY 89:3221-3235(2015).
Rommler, F; Hammel, M; et al. Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7-and TLR9-Mediated Immune Responses of Human Immune Cells. PLOS ONE 10:-(2015).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
08/11/2020

    Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

    05/04/2020

      A reliable manufacturer ensures the production and purification of TLR7 protein, maintaining its quality and purity.

      01/02/2019

        TLR7 protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

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