TMED10
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Official Full Name
transmembrane emp24-like trafficking protein 10 (yeast)
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Overview
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. -
Synonyms
TMED10; transmembrane emp24-like trafficking protein 10 (yeast); transmembrane emp24 domain-containing protein 10; P24(DELTA); TMP21; p24delta; p24delta1; p24 family protein delta-1; transmembrane protein Tmp21; 21 kDa transmembrane trafficking protein; 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- C
- mFc
- Fc
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | TMED10-15897H | Recombinant Human TMED10, His-tagged | E.coli | His | 32-185aa | |
Human | TMED10-536H | Recombinant Human TMED10 Protein, Fc-tagged | HEK293 | Fc | ||
Human | TMED10-3270H | Recombinant Human TMED10, His-tagged | E.coli | His | 40-186aa | |
Human | TMED10-670HCL | Recombinant Human TMED10 lysate | HEK293 | N/A | ||
Human | TMED10-1054H | Recombinant Human TMED10 protein(Met1-Arg185), mFc-tagged | HEK293 | C-mFc | Met1-Arg185 | |
Human | TMED10-3271H | Recombinant Human TMED10 protein, GST-tagged | E.coli | GST | 40-186 aa | |
Mouse | TMED10-16873M | Recombinant Mouse TMED10 Protein | Mammalian Cell | His | ||
Mouse | TMED10-9267M | Recombinant Mouse TMED10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | TMED10-9267M-B | Recombinant Mouse TMED10 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | TMED10-6098R | Recombinant Rat TMED10 Protein | Mammalian Cell | His | ||
Rat | TMED10-5755R | Recombinant Rat TMED10 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | TMED10-5755R-B | Recombinant Rat TMED10 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Homo sapiens (Human) | RFL17760HF | Recombinant Full Length Human Transmembrane Emp24 Domain-Containing Protein 10(Tmed10) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (32-219) | |
Zebrafish | TMED10-12728Z | Recombinant Zebrafish TMED10 | Mammalian Cell | His | ||
Chicken | TMED10-1621C | Recombinant Chicken TMED10 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TMED10 Related Articles
TMED10 involved in several pathways and played different roles in them. We selected most pathways TMED10 participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMED10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Asparagine N-linked glycosylation | PPP6R3;GOLGA2;NSFA;ST8SIA3;TMED10;TRAPPC3;NEU3;NANP;NAPB |
COPII (Coat Protein 2) Mediated Vesicle Transport | TMED2;TFG;TRAPPC4;TMED10;TRAPPC6BL;NAPAB;NAPAA;SERPINA1L;GOLGA2 |
Cargo concentration in the ER | CTSC;MIA3;LMAN2L;LMAN2;SEC24A;CNIH;CTSZ;SERPINA1L;MCFD2 |
ER to Golgi Anterograde Transport | CTAGE5;CNIH;NSFA;CTSC;NAPG;AREG;TRAPPC9;PPP6R1;NAPAA |
Membrane Trafficking | CTAGE5;CLVS1;NAPG;PPP6R3;COPB1;COPB2;YIPF6;HIP1RB;ARCN1A |
Metabolism of proteins | GRPEL1;KCNA6;TPP1;APCS;ARSI;MPDU1A;IGFBP2;FBXW4;THSD1 |
Post-translational protein modification | TRAPPC2L;ST8SIA3;ADAMTS20;DPH3;NAPAA;SEC22C;TRAPPC6A;SAE1;TRAPPC9 |
Transport to the Golgi and subsequent modification | PPP6R3;SEC23IP;NAPB;NAPG;TRAPPC10;ANKRD28;PPP6R1;SEC22A;TRAPPC9 |
TMED10 has several biochemical functions, for example, protein binding, protein complex binding, syntaxin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMED10 itself. We selected most functions TMED10 had, and list some proteins which have the same functions with TMED10. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | APOH;OSBPL3;NEK11;KLK5;LETM1;SCAF8;EML2;GIT1;ZNF576 |
protein complex binding | NDUFA8;GIT2;CYFIP1;PDX1;NFKBIA;STRN;ADM2;MAPK8IP2;ATP6V1B1 |
syntaxin binding | SYT11;GOLGA2;SYT4;SCFD1;PLDN;CPLX3;ABCA1;SNAP29;NAPGA |
TMED10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMED10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMED10.
TMED2; NCSTN; SURF4; PTPN2
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