Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

TNIK

Official Full Name

TRAF2 and NCK interacting kinase
Overview

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK;domain that serves a regulatory function (Fu et al., 1999 (PubMed 10521462)).
Synonyms

TNIK; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase; KIAA0551;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
Insect Cell
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TNIK-1499H	Active Recombinant Human TNIK, GST-tagged	Sf9 Insect Cell	GST	1-367 aa	Inquiry
Human	TNIK-20H	Recombinant Human TNIK protein, GST-tagged	Wheat Germ	GST	1 a.a. - 538 a.a.	Inquiry
Human	TNIK-31580TH	Recombinant Human TNIK	Sf9 Insect Cell	N/A	367 amino acids	Inquiry
Human	TNIK-85H	Recombinant Human TNIK protein, Flag-tagged, Biotinylated	Insect Cell	Flag		Inquiry
Human	TNIK-1801HCL	Recombinant Human TNIK cell lysate		N/A		Inquiry
Human	TNIK-1073H	Recombinant Human TNIK Protein (D11-G314), Tag Free	Insect Cell	No tag	D11-G314	Inquiry
Human	TNIK-1072H	Recombinant Human TNIK Protein (D11-G314), His tagged	Insect Cell	His	D11-G314	Inquiry
Rhesus Macaque	TNIK-4877R	Recombinant Rhesus monkey TNIK Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TNIK-4691R	Recombinant Rhesus Macaque TNIK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TNIK-4691R-B	Recombinant Rhesus Macaque TNIK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

TNIK involved in several pathways and played different roles in them. We selected most pathways TNIK participated on our site, such as Cellular Senescence, Cellular responses to stress, Oxidative Stress Induced Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNIK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular Senescence	HMGA1;EP400;TERF2IP;CDKN2B;SUZ12A;TNIK;POT1;UBN1;EHMT2
Cellular responses to stress	RBB4L;RB1CC1;PHC3;GABARAPL2;MOV10;ATG7;EED;CDKN2C;KIAA1967
Oxidative Stress Induced Senescence	SUZ12A;PHC1;CBX8;SUZ12;CBX8A;TNIK;BMI1B;CBX6A;RING1
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	MYOG;T;BCL9;CYR61;CDX1;AES;TCF4;TLE4;CDX4
TNF receptor signaling pathway	MAP4K5;NRK;RFFL;TNIK

TNIK has several biochemical functions, for example, ATP binding, NOT MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNIK itself. We selected most functions TNIK had, and list some proteins which have the same functions with TNIK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MAP3K12;TNIKA;SMARCA5;STK24A;HSP70;EPHA2A;ABCB8;SUCLA2;MAP3K4
NOT MAP kinase kinase kinase kinase activity	MAP4K4;TNIKB;MINK1;NRK;TNIK;TNIKA
protein binding	PCM1;CIAO1;MYOG;SRPK3;OCLN;TPM4;UTP23;CSTF3;CSPG5
protein kinase activity	ROCK2B;PRKACBB;MAP4K1;PRKAA1;GM4922;TEX14;FGFR1A;CCND1;BMPR1AA
protein serine/threonine kinase activity	PBK;MAP3K9;PIK3R4;SNRK;NEK7;MAP3K13;ACVR1L;DCAMKL2;SMOK3A

TNIK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNIK here. Most of them are supplied by our site. Hope this information will be useful for your research of TNIK.

CTNNB1; TCF7L2; Dlg4; 51460873; PDCD5; EIF3H; SEPT4; PPIH; BUB3; GLRX3; GOT2; SOD2; RPN2; ANXA2