TNIP2
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Official Full Name
TNFAIP3 interacting protein 2
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Overview
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK;(see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 (PubMed 11390377);;Papoutsopoulou et al., 2006 (PubMed 16633345)). -
Synonyms
TNIP2; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2; ABIN 2; FLIP1; KLIP; MGC4289; A20 binding inhibitor of NF kappaB activation 2; LKB1 interacting protein; OTTHUMP00000115298; OTTHUMP00000219012; OTTHUMP00000219013; fetal liver LKB1-interacting protein; A20-binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TNIP2 involved in several pathways and played different roles in them. We selected most pathways TNIP2 participated on our site, such as Activated TLR4 signalling, Cytokine Signaling in Immune system, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNIP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | TANK;PELI2;DUSP3B;DUSP7;MAPK14;DUSP6;ALCAMB;TAB1;ATF2 |
| Cytokine Signaling in Immune system | PELI3;NRG3;SPTBN2;IFIT8;GHRB;TRIM68;IFIT10;FRS2;PEA15 |
| Immune System | LRSAM1;CD300E;CSH1;ASB4;SIGIRR;RAP1GAP2B;CRTAM;MYO9B;LTF |
| Innate Immune System | DHX9;ABI2;NCKAP1;CLEC4D;TANK;CLEC5A;CLEC4A;PCBP2;DEFB129 |
| Interleukin-1 signaling | PELI2;IL1RN;PELI1;NOD1;IRAK3;TNIP2;PELI3 |
| MAP kinase activation in TLR cascade | DUSP3;NOD1;TNIP2;DUSP3B |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | |
| MyD88 cascade initiated on plasma membrane | PELI1;PELI2;DUSP3B;ALCAMB;S100B;TLR10;DHX9;TNIP2;PELI3 |
TNIP2 has several biochemical functions, for example, polyubiquitin binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNIP2 itself. We selected most functions TNIP2 had, and list some proteins which have the same functions with TNIP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| polyubiquitin binding | BRE;FAM175A;UBQLN4;BAG6;DZIP3;RAD23A;VCP;UBXN1;TNIP2 |
| protein binding | ABLIM3;S100P;ATE1;FAM81B;ACVR2A;HTR1B;FANCL;UBE2D3;PRKRIR |
| protein kinase binding | ATF2;MAP2K3;CD3E;GRB2;STAT3;KCNQ3;E2F1;TCF7L2;USF1 |
TNIP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNIP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNIP2.
MAP3K8; IKBKG; STK11
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