TNK2
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Official Full Name
tyrosine kinase, non-receptor, 2
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Overview
Ack1 and Ack2 (activated cdc42-associated kinase 1 and 2) are non-receptor tyrosine kinases that consist of a tyrosine kinase core, an SH3 domain, a cdc42/Rac-binding (CRIB) domain, a Ralt homology region and a proline-rich region (1,2). Ack1 and 2 are th -
Synonyms
TNK2; tyrosine kinase, non-receptor, 2; activated CDC42 kinase 1; ACK; ACK1; activated Cdc42 associated kinase 1; p21cdc42Hs; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2; ACK-1; FLJ44758; FLJ455;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- Insect Cell
- Mammalian Cell
- Sf21
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
TNK2 involved in several pathways and played different roles in them. We selected most pathways TNK2 participated on our site, such as CDC42 signaling events, EGFR1 Signaling Pathway, Focal Adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDC42 signaling events | EPS8;ARPC1B;ARPC5;CFL1;IQGAP3;ACTR2;ARPC3;ARPC2;PAK4 |
| EGFR1 Signaling Pathway | ZNF259;GRB7;DOK2;MAP3K2;ZPR1;ELF3;PITPNAA;TNIP1;RGS5B |
| Focal Adhesion | KDRL;PIK3R5;ITGB7;SHC1;FLT1;RHOAC;CAV1;PXN;PAK2 |
| G13 Signaling Pathway | ARHGEF1A;CFL2;CIT;TNK2;DIAPH1;GNA13;MYBPH;RHPN2;RTKN |
TNK2 has several biochemical functions, for example, ATP binding, GTPase inhibitor activity, WW domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNK2 itself. We selected most functions TNK2 had, and list some proteins which have the same functions with TNK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GSK3AB;ROCK2B;MYO5B;BMPR2A;MYO19;DICER1;MAPK4;AK7;GPHN |
| GTPase inhibitor activity | RHOH;CDC42SE1;PDE6D;SLIT2;CPEB2;GPS2;RTKN;GPS1;IPO5 |
| WW domain binding | TRP63;PPARG;SCNN1B;TCEAL1;PMEPA1;KIF20B;WBP5;TCEAL7;TP63 |
| epidermal growth factor receptor binding | BTC;YES1;TNK2;EPGN;ERBB4;PLSCR1;AREG;ARF4;SNX4 |
| hormone receptor binding | TNK1;JAK2B;JAK3;TNK2B;SRC;TNK2;JAK2A |
| identical protein binding | NONO;PCM1;BIN1;MAP3K13;MDM2;GM5077;AGXT2;DRD4;SH3GL3 |
| metal ion binding | TRIM43C;ZMYND19;NKD2A;MAP3K4;CAPN8;B3GNT1;TRIM30A;CSHL1;MOBKL2B |
| non-membrane spanning protein tyrosine kinase activity | FYNA;FGR;FRK;MATK;BLK;JAK2B;BMX;YRK;LYN |
| protein binding | SLC1A2;SPON2;PDLIM4;PTPLAD1;TMEM14C;ANXA2;PDE2A;TRIP4;SOAT1 |
| protein serine/threonine kinase activity | AURKB;ILK;PRKCDA;PRKD1;MAP2K5;PIM3;RPS6KB2;STK36;ACVR2AA |
| protein serine/threonine/tyrosine kinase activity | DYRK3;DYRK1AA;ACVR2B;TESK2;AKT1;DYRK1A;RPS6KA2;TNK2;PRKAA2 |
| protein tyrosine kinase activity | FGFR3;BTK;TEK;EPHA4A;CLK3;HCK;TESK1;FES;KDR |
TNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNK2.
CLTC; GRB2; NCK1; CDC42; SH2D1A; GALT
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