TNNI1
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Official Full Name
troponin I, skeletal, slow 1
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Overview
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. -
Synonyms
Tnni1; troponin I, skeletal, slow 1; TNNI1; troponin I, skeletal, slow 1; troponin I, slow skeletal muscle; troponin I, slow-twitch isoform; ssTnI; AI747285; 2700018B22Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- DDK
- Flag
- His
- His (Fc)
- Avi
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TNNI1 involved in several pathways and played different roles in them. We selected most pathways TNNI1 participated on our site, such as Muscle contraction, Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Muscle contraction | TCAP;DESMA;MYL6B;MYL1;MYLZ3;MYBPC2;DES;TNNI2;MYL12B |
| Striated Muscle Contraction | ACTA1B;DES;TMOD1;MYL1;TNNT3;TNNI2A.1;CMLC1;TNNT3A;TNNT3B |
TNNI1 has several biochemical functions, for example, actin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI1 itself. We selected most functions TNNI1 had, and list some proteins which have the same functions with TNNI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | WIPF2B;ACTN4;LIMCH1A;WASLA;EPB41L3;EPB41L2;MTSS1LA;PARVAA;DMTN |
| metal ion binding | ZC3H3;RORCA;SH3RF3;PRSS37;NCALDA;ZNF37A;THAP10;BTR06;ERCC5 |
| protein binding | BCL9;PIGS;UPP2;GNAI1;MTCH1;VCAN;ELL;CTSG;RASL10B |
TNNI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI1.
PNMA1; MDFI; TNNC1; CCDC85B
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