tnni2
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  • Official Full Name
  • troponin T type 2 (cardiac)
  • Background
  • Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. Troponin I, slow skeletal muscle is a protein that in humans is encoded by the TNNI1 gene. Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene
  • Synonyms
  • TNNI2; troponin I type 2 (skeletal, fast); DA2B; FSSV; fsTnI; AMCD2B; troponin I, fast skeletal muscle; OTTHUMP00000014141; OTTHUMP00000014142; OTTHUMP00000014143; troponin I fast twitch 2; troponin I, skeletal, fast; troponin I, fast-twitch isoform; fast-twitch skeletal muscle troponin I; troponin I, fast-twitch skeletal muscle isoform
Cat.#:TNNI2-15HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNNI2, MYC/DDK-tagged
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Cat.#:TNNI2-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNNI2, MYC/DDK-tagged
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Cat.#:TNNI2-17HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TNNI2, GST-tagged
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Cat.#:TNNI2-1996HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI2 protein
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Cat.#:TNNI2-30870THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI2
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Cat.#:TNNI2-3332HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNNI2, His-tagged
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Cat.#:TNNI2-371HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human troponin I type 2 (skeletal, fast), His-tagged
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Cat.#:TNNI2-17195MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNNI2 Protein
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Cat.#:Tnni2-7945MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnni2 protein, His-tagged
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Cat.#:TNNI2-6208RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNNI2 Protein
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Cat.#:Tnni2-7946RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnni2 protein, His-tagged
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Cat.#:TNNI2-6968CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNNI2
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Cat.#:TNNI2-1802HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TNNI2 cell lysate
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Involved Pathway

TNNI2 involved in several pathways and played different roles in them. We selected most pathways TNNI2 participated on our site, such as Muscle contraction, Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Muscle contraction
DMD; TMOD2; SMYHC2; TNNT3A; MYL12A; TNNT1; TNNT3B; TCAP; TNNI2A.1; VIML
Striated Muscle Contraction
TMOD1; SMYHC2; MYBPC2; TCAP; CMLC1; TNNT3A; TMOD4; DESMA; TNNI2A.1; TNNI2

Protein Function

TNNI2 has several biochemical functions, for example, contributes_to actin binding, protein binding, troponin T binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI2 itself. We selected most functions TNNI2 had, and list some proteins which have the same functions with TNNI2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to actin binding
Related Protein TNNC2; TNNI2; TNNT3
Function protein binding
Related Protein CDH5; CRLF1; MED20; GPR177; DCP1A; LRGUK; ADAM1B; PTBP3; PPP6R2; FBXL12
Function troponin T binding
Related Protein TNNI2; TNNC1; TNNT1; TNNI3

Interacting Protein

TNNI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI2.
TRIM63; SMURF2