tpi1
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  • Official Full Name
  • triosephosphate isomerase 1
  • Background
  • This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • TPI1; triosephosphate isomerase 1; triosephosphate isomerase; MGC88108; TIM; TPI 1; TPI; Triose phosphate isomerase 1; Triose phosphate isomerase; OTTHUMP00000165244; triose-phosphate isomerase
Cat.#:TPI1-640HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPI1 Protein, His-tagged
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Cat.#:TPI1-2845HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Triosephosphate Isomerase 1, His-tagged
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Cat.#:TPI1-305HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPI1 Protein, His-tagged
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Cat.#:TPI1-31613THTag:
Source (Host):Species:Human
Product nameRecombinant Human TPI1
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Cat.#:TPI1-17254MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TPI1 Protein
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Cat.#:TPI1-6241RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TPI1 Protein
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Cat.#:TPI1-7001CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TPI1
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Cat.#:TPI1-846HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TPI1 293 Cell Lysate
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Involved Pathway

TPI1 involved in several pathways and played different roles in them. We selected most pathways TPI1 participated on our site, such as Glycolysis / Gluconeogenesis, Fructose and mannose metabolism, Inositol phosphate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
GAPDH; LDHC; PGK2; GPI1; ALDH2.1; ALDH2; ADH4; PGAM2; ENO2; ALDOCA
Fructose and mannose metabolism
ENOSF1; ALDOAA; HK2; ALDOCB; HKDC1; AKR1B8; PFKFB1; GMPPB; AKR1B10; HK1
Inositol phosphate metabolism
INPP5KA; TPI1A; MTMR1B; INPPL1; MTMR3; INPP4A; PLCB4; PIP4K2A; PLCD1A; NUDT3A
Metabolic pathways
SMPD4; MCCC2; PIP5KL1; PSPH; PIP5K1A; ST3GAL3B; KCNG4; NAGLU; CYP27A1; NOS3
Carbon metabolism
GPT; PSAT1; IDH3A; PRPS1L1; TPI1B; GLUD2; SHMT1; TKTB; ME2; PGLS
Biosynthesis of amino acids
PAH; GPT; ENO2; PGK2; TAT; IDH1; PKMA; pykF; IDH3G; GPT2

Protein Function

TPI1 has several biochemical functions, for example, protein binding, triose-phosphate isomerase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPI1 itself. We selected most functions TPI1 had, and list some proteins which have the same functions with TPI1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CYP2S1; HELLS; FBXW11; CCDC123; CADM1; CDK5RAP3; IFNA4; LRRC4C; NIPA2; GNAI3
Function triose-phosphate isomerase activity
Related Protein TPI1A; TPI1; TPI1B
Function ubiquitin protein ligase binding
Related Protein SUMO2; PRKAR2B; AICDA; LRPPRC; CUL4A; RIPK1; DNM1L; PPARGC1A; PA2G4; WFS1

Interacting Protein

TPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPI1.
PCNA; TERF1; SP1; YWHAZ; EGFR; CCL11; SETDB1; MAPK6; DDX24; POT1; LIPT1; ere_dna; GABARAP; NS; ATF2; polg_hcvh