TPO
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Official Full Name
thyroid peroxidase
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Overview
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. -
Synonyms
TPO; thyroid peroxidase; MSA; TPX; TDH2A; thyroperoxidase; thyroid microsomal antigen; EC 1.11.1.8; Thyroid peroxidase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Baculovirus-Insect cells
- CHO
- E.coli
- HEK cell
- HEK293
- HEK293 cells
- HEK293T
- Human cells
- Human Thyroids
- Insect Cell
- Insect cells
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Yeast
- C
- His
- Fc
- Flag
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TPO Related Articles
- TPO Related Research Area
TPO involved in several pathways and played different roles in them. We selected most pathways TPO participated on our site, such as Tyrosine metabolism, Metabolic pathways, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | AOC2;AOX2P;ALDH1A3;AOX3;HPD;DCT;AOC3;ADH2-2;HPDB |
| Metabolic pathways | PMM1;PCYT2;PAFAH1B2;INPP5J;PRDX6;TPH1A;DPM1;HMGCLL1;CSGALNACT2 |
| Thyroid hormone synthesis | GPX7;TTF2;GPX3;GPX1;PRKACA;GPX6;ATP1B1;ATP1B3;LRP2 |
| Autoi | TSHB;HLA-B;HLA-DRA;H2-Q10;Ifna11;HLA-DQB1;FASLG;IFNA6;IFNA13 |
| ne thyroid disease | H2-AB1;HLA-DRB5;HLA-DMB;CD28;TG;HLA-B;Fasl;IFNA13;TSHB |
TPO has several biochemical functions, for example, calcium ion binding, heme binding, iodide peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPO itself. We selected most functions TPO had, and list some proteins which have the same functions with TPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | S100A3;SYT3;MYLPF;NCL;MYL2B;SWAP70B;EFHC2;CDH19;PCDHB13 |
| heme binding | PTGESL;CYP2P9;HBA-X;NOX4;MB;CYP3C1;CYP27A1;CBSB;CYP8B1 |
| iodide peroxidase activity | IYD;TPO |
| peroxidase activity | GPX1B;PRDX1;TPO;MPO;GPX8;GPX5;PXDN;EPX;PRDX5 |
TPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPO here. Most of them are supplied by our site. Hope this information will be useful for your research of TPO.
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