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TPSAB1

Official Full Name

tryptase alpha/beta 1
Overview

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3 UTR and contain tandem repeat sequences at the 5 flank and 3 UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Synonyms

TPSAB1; tryptase alpha/beta 1; TPS1, TPS2, TPSB1, tryptase beta 1; tryptase alpha/beta-1; tryptase alpha II; tryptase beta I; tryptase I; tryptase II; tryptase III; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta-1; tryptase alpha-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Native Proteins

Species

Human
Mouse
Rat

Source

E.coli
Insect Cell
Lung
Mammalian cells
Yeast

Tag

C
His
SUMO
Myc
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TPSAB1-7161H	Recombinant Human Tryptase Alpha/Beta 1, His-tagged	E.coli	His	31-275aa	Inquiry
Human	TPSAB1-1815HCL	Recombinant Human TPSAB1 cell lysate		N/A		Inquiry
Human	TPSAB1-241H	Recombinant Human TPSAB1 Protein, His-tagged	Insect Cell	His	31-275aa	Inquiry
Human	TPSAB1-478H	Recombinant Human TPSAB1 Protein, His-tagged	E.coli	N-His	Ile31-Pro275	Inquiry
Human	TPSAB1-3195H	Recombinant Human TPSAB1 Protein (Ile31-Pro275), His tagged	E.coli	His	Ile31-Pro275	Inquiry
Human	TPSAB1-6507H	Recombinant Human TPSAB1 Protein (Met1-Val133, Ser135-Gly199, Asp201-Pro275), C-His tagged	Mammalian cells	C-His	Met1-Val133, Ser135-Gly199, Asp201-Pro275	Inquiry
Human	TPSAB1-02H	Active Native Human TPSAB1 Protein	Lung			Inquiry
Mouse	Tpsab1-1460M	Recombinant Mouse Tpsab1 protein, His-tagged	E.coli	His	Ser149~Phe273 (Accession # Q02844)	Inquiry
Mouse	TPSAB1-1542M	Recombinant Mouse TPSAB1 Protein (35-267 aa), His-tagged	Yeast	His	35-267 aa	Inquiry
Mouse	TPSAB1-840M	Recombinant Mouse TPSAB1 Protein (35-267 aa), His-tagged	E.coli	His	35-267 aa	Inquiry
Rat	Tpsab1-1462R	Recombinant Rat Tpsab1 protein, His-tagged	E.coli	His	Ile29~Pro148	Inquiry
Rat	Tpsab1-3614R	Recombinant Rat Tpsab1 protein, His-SUMO & Myc-tagged	E.coli	His-SUMO & Myc	29-273aa	Inquiry
Rat	Tpsab1-479R	Recombinant Rat Tpsab1 Protein, His-tagged	E.coli	N-His	Ile29-Phe273	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TPSAB1 Related Research Area

TPSAB1 involved in several pathways and played different roles in them. We selected most pathways TPSAB1 participated on our site, such as Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPSAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activation of Matrix Metalloproteinases	MGC174857;MGC174152;LOC100686744;MMP24;MGC174155;CTRB1;TIMP2B;TIMP2;FURINB
Degradation of the extracellular matrix	MMP13;FAM49BA;ADAM15;TIMP2A;ADAMTS18;TIMP2B;LOC100686744;MMP8;ADAM8A
Extracellular matrix organization	COL4A3;EMID2;CEACAM6;COL8A2;FAM49BA;TLL2;MMP13;LAMB1B;FN1B

TPSAB1 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPSAB1 itself. We selected most functions TPSAB1 had, and list some proteins which have the same functions with TPSAB1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	RNF138;FTH1;ISOC2;RUNX1T1;UBL4B;HYPK;SPA17;ZNF649;LRCH1
serine-type endopeptidase activity	F12;LONP1;FURINB;TMPRSS13A;TMPRSS11F;MST1;KLK15;C1R;KLK1
serine-type peptidase activity	ENDOU;FURINA;MCPT9;PROCA;PRSS59.1;HPN;TMPRSS11G;TMPRSS7;KLK5

TPSAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPSAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPSAB1.

NCK1; PIK3R1

Colon Cancer Biomarkers

Mast Cells

Serine Proteases and Regulators