traf5
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  • Official Full Name
  • TNF receptor-associated factor 5
  • Background
  • The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF);protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc;fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor;superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor;(TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have;been characterized.
  • Synonyms
  • TRAF5; TNF receptor-associated factor 5; RNF84; RING finger protein 84; MGC:39780
Cat.#:TRAF5-842HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF5 Protein (1-557 aa), His-SUMO-tagged
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Cat.#:TRAF5-559HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF5 Protein, His-tagged
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Cat.#:TRAF5-3388HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF5, GST-tagged
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Cat.#:TRAF5-17290MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF5 Protein
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Cat.#:TRAF5-5793CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TRAF5
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Cat.#:TRAF5-819HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF5 293 Cell Lysate
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Involved Pathway

TRAF5 involved in several pathways and played different roles in them. We selected most pathways TRAF5 participated on our site, such as NF-kappa B signaling pathway, TNF signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
PIDD1; TICAM2; TRAF1; CCL21; TNFRSF13C; CD40; BCL2A1; ERC1; IL1R1; TRAF2
TNF signaling pathway
MAP2K3; MMP3; TRAF2; FOS; CXCL2; RPS6KA4; IKBKG; TNF; CXCL5; CASP7
Herpes simplex infection
TAF5; IL1B; LTA; SRSF1A; TRAF6; STAT2; DAXX; SFRS9; HLA-DMB; HLA-DOA
Epstein-Barr virus infection
POLR3G; HLA-G; POLR3F; STAT3; POLR3GL; PSMD8; POLR2G; MAPK12; HLA-F; GSK3B
Pathways in cancer
Fgf15; FIGF; FGF17; GNAI3; FGF18; RBX1; GLI2; HDAC2; WNT2; TGFB2
Viral carcinogenesis
SCRIB; H2BFWT; PIK3CD; HIST1H2BB; HIST1H2BG; HDAC2; TP53; SNW1; CDK1; KAT2A
Small cell lung cancer
CYCS; LAMB1; TRP53; ITGA3; RB1; COL4A1; ITGA2; RXRB; PIK3R5; ITGA2B

Protein Function

TRAF5 has several biochemical functions, for example, protein binding, signal transducer activity, thioesterase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF5 itself. We selected most functions TRAF5 had, and list some proteins which have the same functions with TRAF5. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TBL3; IER3; CPNE3; LEO1; SRSF7; LAMTOR1; CLNK; TRIM35; PRDM5; GTF3C3
Function signal transducer activity
Related Protein PARAPINOPSINB; V2RH32; ZDHHC13; ECM1; STAT2; OLFR50; OLFR488; TRHRB; PTGER2B; SH2B1
Function thioesterase binding
Related Protein CALM1; RAC1; TRAF6; CDC42; TRAF4; TRAF1; TRAF2; TRAF3; TRAF5; CALM3
Function ubiquitin protein ligase binding
Related Protein PPARGC1A; DIO2; PRKACB; SPOP; EGFR; RNF34; UBE2KB; PACRG; CUL9; TRAF2
Function ubiquitin-protein transferase activity
Related Protein UBE2E1; TRIM33; ARIH2; TRAF7; RNF6; RNF41; RNF141; UBE2O; TNFAIP3; BIRC5B
Function zinc ion binding
Related Protein PRKCBP1L; USP39; ZDHHC2; TRIM4; C6AST4; MSL2; ZCCHC8; RAI1; LHX6; ZFAND5

Interacting Protein

TRAF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF5.
TRAF6; NMI; TNFRSF14; SDCBP

TRAF5 Related Articles

Xiang, Q; Chen, L; et al. TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis. ARTHRITIS RESEARCH & THERAPY 15:-(2013).
Snell, LM; Lin, GHY; et al. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. IMMUNOLOGICAL REVIEWS 244:197-217(2011).