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TRAF5

  • Official Full Name

    TNF receptor-associated factor 5

  • Overview

    The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF);protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc;fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor;superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor;(TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have;been characterized.
  • Synonyms

    TRAF5; TNF receptor-associated factor 5; RNF84; RING finger protein 84; MGC:39780;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRAF5-3388H Recombinant Human TRAF5, GST-tagged E.coli GST C-term-349aa
Human TRAF5-819HCL Recombinant Human TRAF5 293 Cell Lysate HEK293 N/A
Human TRAF5-6309H Recombinant Human TRAF5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TRAF5-559H Recombinant Human TRAF5 Protein, His-tagged E.coli His Gln181~Arg437
Human TRAF5-480H Recombinant Human TRAF5 Protein, His-tagged E.coli N-His Lys353-Leu557
Human TRAF5-842H Recombinant Human TRAF5 Protein (1-557 aa), His-SUMO-tagged E.coli His/SUMO 1-557 aa
Human TRAF5-6511H Recombinant Human TRAF5 Protein (Gln181-Arg437), His tagged E.coli His Gln181-Arg437
Human TRAF5-3999H Recombinant Human TRAF5 protein, His-tagged E.coli His 1-60 aa
Mouse TRAF5-17290M Recombinant Mouse TRAF5 Protein Mammalian Cell His
Mouse Traf5-6620M Recombinant Mouse Traf5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TRAF5-9559M-B Recombinant Mouse TRAF5 Protein Pre-coupled Magnetic Beads HEK293
Mouse TRAF5-9559M Recombinant Mouse TRAF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TRAF5-5793C Recombinant Chicken TRAF5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRAF5 Related Articles
  • TRAF5 Related Research Area

TRAF5 involved in several pathways and played different roles in them. We selected most pathways TRAF5 participated on our site, such as NF-kappa B signaling pathway, TNF signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayTRAF2;BCL2A1;LRDD;PIAS4;Ccl21a;BCL2L1;Ccl21c;IKBKB;CCL19
TNF signaling pathwayPIK3R3;CXCL10;MAPK1;PIK3R1;CREB3L3;SELE;MMP9;TRAF5;PIK3R5
Herpes simplex infectionIL12BA;C3A.1;SRSF2;IFNB;OAS1A;PML;BLA;CD74;TAF5L
Epstein-Barr virus infectionPIK3CD;YWHAB;MAPK11;FCER2;HLA-A;FGR;PSMC4;TNFAIP3;PSMC5
Pathways in cancerDAPK3;BID;PDGFRB;RARA;IL6;WNT7A;GNG8;Fasl;PLCG1
Viral carcinogenesisRB1;GTF2A1;HIST1H2BK;HIST1H2BQ;CDK1;RANBP1;DNAJA3;PIK3CA;SCRIB
Small cell lung cancerCYCS;IKBKB;AKT2;ITGA2;LAMA4;LAMB2;SKP2;TRP53;RARB

TRAF5 has several biochemical functions, for example, protein binding, signal transducer activity, thioesterase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF5 itself. We selected most functions TRAF5 had, and list some proteins which have the same functions with TRAF5. You can find most of the proteins on our site.

Function Related Protein
protein bindingTRAPPC5;RARG;UBE2D3;PTEN;TBCD;SYT11;EMP3;CDK16;PSAP
signal transducer activityTACR1A;CXCR4B;HCAR1-2;VMN1R43;ADRB3A;TAS2R138;BMX;GNAO1A;VMN1R52
thioesterase bindingCALM2;CALM1;TRAF1;TRAF3;HAUS7;CDC42;TRAF5;CALM;TRAF4
ubiquitin protein ligase bindingSKI;UBE2J1;CHEK2;LYN;DNM1L;TOLLIP;POU5F1;ERBB2;JAK1
ubiquitin-protein transferase activityFBXO21;TRIM27;TRIM2;NEDD4L;UBA1;SKP1;UBE2E3;RNF182;UBE2E1
zinc ion bindingCar2;JUB;PPARAB;ZDHHC13;CPA5;RAG2;SHPRH;C11orf54;TAF2

TRAF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF5.

TRAF6; NMI; TNFRSF14; SDCBP

Xiang, Q; Chen, L; et al. TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis. ARTHRITIS RESEARCH & THERAPY 15:-(2013).
Snell, LM; Lin, GHY; et al. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. IMMUNOLOGICAL REVIEWS 244:197-217(2011).
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