trex1
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  • Official Full Name
  • three prime repair exonuclease 1
  • Background
  • This gene encodes the major 3->5 DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3 ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TREX1; three prime repair exonuclease 1; AGS1, Aicardi Goutieres syndrome 1; DRN3; DNase III; 3 repair exonuclease 1; 3-5 exonuclease TREX1; CRV; AGS1; HERNS; DKFZp434J0310
Cat.#:TREX1-8086HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TREX1 protein, His-tagged
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Cat.#:TREX1-17326MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TREX1 Protein
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Cat.#:TREX1-803HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TREX1 293 Cell Lysate
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Involved Pathway

TREX1 involved in several pathways and played different roles in them. We selected most pathways TREX1 participated on our site, such as Cytosolic DNA-sensing pathway, Cytosolic sensors of pathogen-associated DNA, IRF3-mediated induction of type I IFN, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytosolic DNA-sensing pathway
IL33; TMEM173; CCL4L2; RIPK3; IFN-a; Ifna11; OSTN; IKBKB; POLR3G; DDX58
Cytosolic sensors of pathogen-associated DNA
ALCAMB; APPB; CRCP; RIPK3; TICAM1; MB21D1; POLR3GLA; POLR3C; LRRFIP1; NLRP4E
IRF3-mediated induction of type I IFN
NLRP4; DDX41; NLRP4B; IFI16; NLRP4C; TREX1; NLRP4E
Immune System
TRIM46; KIF22; PIK3AP1; ASB14; GRAP2A; BTLA; RNF182; SIGLEC6; AP1M2; TNFSF13B
Innate Immune System
WIPF3; HERC5; DEFA5; POLR3H; S100B; ACTR2B; NOD1; CFHL3; ABI2; BTR30
Regulation by TREX1
TREX1
Regulation of innate immune responses to cytosolic DNA
NLRP4B; NLRP4; NLRP4C; TRIM56; NLRP4E; DDX41; TREX1
STING mediated induction of host immune responses
NLRP4B; NLRP4E; NLRP4C; DDX41; MB21D1; IFI16; NLRP4; TREX1

Protein Function

TREX1 has several biochemical functions, for example, 3-5 exonuclease activity, 3-5-exodeoxyribonuclease activity, MutLalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREX1 itself. We selected most functions TREX1 had, and list some proteins which have the same functions with TREX1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5 exonuclease activity
Related Protein EXOSC10; POLG; TREX1; EXD1; ERI1; EXD2; REXO2; RAD9; APEX1; WRN
Function 3-5-exodeoxyribonuclease activity
Related Protein TREX2; POLD1; TREX1
Function MutLalpha complex binding
Related Protein TREX1; PCNA
Function MutSalpha complex binding
Related Protein MUTYH; TREX1
Function exodeoxyribonuclease III activity
Related Protein TREX2; RAD1; RAD9; TREX1; RAD9A
Function metal ion binding
Related Protein SMPD4; TRIM7; ASNA1; ZFP280D; ZFP458; ZNF480; PHC2A; ATP2C1; ZNF221; TROVE2
Function protein binding
Related Protein BRPF3; GALR2; GLS2; UBAP1; C1QTNF1; LSM6; FABP5; ITGB2; INMT; BCDIN3D
Function protein homodimerization activity
Related Protein TESCA; AOC3; ADRA2A; LHPP; TOX3; XBP1; ASCL1; APOA4; TFRC; ACTN2
Function single-stranded DNA binding
Related Protein RTF1; CTC1; RPA2; NUP35; SSBP3A; YBX1; RAD23A; BLM; ALYREF; RAD23B

Interacting Protein

TREX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREX1.
KRTAP10-7

TREX1 Related Articles

Terao, C; Ohmura, K; et al. Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns The Nagahama Study. ARTHRITIS & RHEUMATOLOGY 66:3395-3403(2014).
Fanouriakis, A; Boumpas, DT; et al. Pathogenesis and treatment of CNS lupus. CURRENT OPINION IN RHEUMATOLOGY 25:577-583(2013).