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TRPA1

  • Official Full Name

    transient receptor potential cation channel, subfamily A, member 1

  • Overview

    The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins.The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
  • Synonyms

    TRPA1; transient receptor potential cation channel, subfamily A, member 1; ANKTM1, ankyrin like with transmembrane domains 1; transient receptor potential cation channel subfamily A member 1; transformation-sensitive protein p120; ankyrin-like with trans;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian cell
  • Mammalian Cell
  • Wheat Germ (in vitro)
  • Flag,Strep II,8His
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPA1-2844H Active Recombinant Human TRPA1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human TRPA1-3431H Recombinant Human TRPA1, His-tagged E.coli His 1-350aa
Human TRPA1-1841HCL Recombinant Human TRPA1 cell lysate N/A
Human TRPA1-345H Recombinant Human TRPA1 protein, His-SUMO-tagged E. coli His-SUMO 957-1119aa
Human TRPA1-1156HFL Recombinant Human TRPA1 protein, His&Flag-tagged HEK293 His&Flag 1-1119 aa
Human TRPA1-1000H Recombinant Human TRPA1 Protein (K2-P1119), Flag, Strep II, 8×His tagged Mammalian cell Flag,Strep II,8His K2-P1119
Human TRPA1-18H Recombinant Human TRPA1 Protein, N-GST-tagged Wheat Germ (in vitro) N-GST 1033-1117 aa
Human TRPA1-343H Recombinant Human TRPA1 Protein, His-tagged E.coli His Asp63~Ile370
Mouse TRPA1-17442M Recombinant Mouse TRPA1 Protein Mammalian Cell His
Mouse TRPA1-9653M Recombinant Mouse TRPA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TRPA1-9653M-B Recombinant Mouse TRPA1 Protein Pre-coupled Magnetic Beads HEK293
Rat TRPA1-6298R Recombinant Rat TRPA1 Protein Mammalian Cell His
Rat TRPA1-5955R Recombinant Rat TRPA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRPA1-5955R-B Recombinant Rat TRPA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRPA1 Related Articles

TRPA1 involved in several pathways and played different roles in them. We selected most pathways TRPA1 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inflammatory mediator regulation of TRP channelsAdcy4;CYP2J5;PRKACG;CYP2C37;MAP2K3;PLCB4;PIK3CG;PIK3R2;PRKACA

TRPA1 has several biochemical functions, for example, channel activity, intracellular ligand-gated calcium channel activity, temperature-gated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPA1 itself. We selected most functions TRPA1 had, and list some proteins which have the same functions with TRPA1. You can find most of the proteins on our site.

Function Related Protein
channel activityAPNL;CHRNB1;GJA8;BCL2;MAL;PANX2;BAX;TRPA1;STEAP1
intracellular ligand-gated calcium channel activityAKR1C1;ITPR1;TRPA1;ITPR3;RYR2
temperature-gated cation channel activityTRPA1;KCNK4

TRPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPA1.

Uckert, S; Sonnenberg, JE; et al. Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human vagina. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 27:16-19(2015).
Fischer, MJM; Balasuriya, D; et al. Direct evidence for functional TRPV1/TRPA1 heteromers. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 466:2229-2241(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do alterations in TRPA1 expression or activity affect chronic pain and hypersensitivity conditions? 12/30/2021

Variations in TRPA1 function can lead to chronic pain disorders and increased sensitivity to stimuli.

How does TRPA1 influence respiratory conditions, such as asthma and cough reflexes? 12/18/2021

TRPA1 affects respiratory health, influencing asthma pathology and cough reflexes.

What role does TRPA1 play in pain perception and nociception? 09/14/2021

TRPA1 plays a crucial role in pain perception, particularly in detecting noxious stimuli.

How does TRPA1 contribute to the sensation of cold and mechanical stimuli? 12/02/2020

TRPA1 contributes to the sensation of cold and mechanical forces, acting as a sensory receptor.

What is the impact of TRPA1 activation on inflammatory and allergic responses? 04/29/2020

Activation of TRPA1 can trigger inflammatory and allergic reactions, amplifying immune responses.

What are the mechanisms by which TRPA1 modulates signal transduction in sensory neurons? 11/11/2019

TRPA1 modulates signal transduction in sensory neurons, playing a role in sensory perception.

How does TRPA1 (Transient Receptor Potential Ankyrin 1) function as a sensor for environmental irritants and chemicals? 02/21/2018

TRPA1 acts as a sensor for environmental irritants, detecting a wide range of chemical stimuli.

Customer Reviews (3)

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Reviews
10/12/2021

    Accurate protein structural analysis, a critical component of our investigations.

    11/26/2019

      Swift and reliable protein sequencing, indispensable for our research success.

      07/29/2018

        Reliable mass spectrometry analysis, pivotal for our proteomics studies.

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