trpm1
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  • Official Full Name
  • transient receptor potential cation channel, subfamily M, member 1
  • Background
  • This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • TRPM1; transient receptor potential cation channel, subfamily M, member 1; melastatin 1 , MLSN1; transient receptor potential cation channel subfamily M member 1; LTRPC1; melastatin-1; long transient receptor potential channel 1; transient receptor potent
Cat.#:TRPM1-17452MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRPM1 Protein
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Cat.#:TRPM1-6300RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRPM1 Protein
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Involved Pathway

TRPM1 involved in several pathways and played different roles in them. We selected most pathways TRPM1 participated on our site, such as Ion channel transport, Stimuli-sensing channels, TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
WNK2; ARHGEF9; GSDMA2; TTYH2; TCIRG1; WNK1; SLC9B2; ATP1A1A.3; CCC2; CUTC
Stimuli-sensing channels
ANO6; TRPA1B; TPCN1; ANO10A; TTYH2; MCOLN2; ASIC1A; SLC9A10; CLCA1; CLCNKA
TRP channels
MCOLN3; TRPV3; TRPC5A; TRPA1A; TRPM4C; TRPC4B; TRPC4; TRPM1A; TRPM4A; TRPA1B
Transmembrane transport of small molecules
FLVCR1; SLC6A1B; TSC22D3; SLC12A5B; MFSD7B; LCN12; ANO10A; SLC6A20; ATP1A1A.3; SLC2A15B

Protein Function

TRPM1 has several biochemical functions, for example, calcium channel activity, cation channel activity, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM1 itself. We selected most functions TRPM1 had, and list some proteins which have the same functions with TRPM1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein AKR1C1; CACNA1SB; CACNG2B; CUL5; CHRNA10; GPM6A; TRPC1; PKD2L2; RYR2; SLC24A2
Function cation channel activity
Related Protein GAR1; TRPM1B; ACCN3; P2RX1; TRPV4; CALHM2; ASIC3; ASIC4A; PKD2L1; GRIN3B
Function ion channel activity
Related Protein SCN12AA; P2RX3B; Chrng; RYR1B; SCN8AA; KCNC3B; KCNH1B; P2RX8; P2RX4B; CHRNA2A

TRPM1 Related Articles

Brown, RL; Xiong, WH; et al. TRPM3 Expression in Mouse Retina. PLOS ONE 10:-(2015).
Agosto, MA; Zhang, ZX; et al. Oligomeric State of Purified Transient Receptor Potential Melastatin-1 (TRPM1), a Protein Essential for Dim Light Vision. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27019-27033(2014).