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TSEN34

  • Official Full Name

    tRNA splicing endonuclease 34 homolog (S. cerevisiae)

  • Overview

    This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    TSEN34; tRNA splicing endonuclease 34 homolog (S. cerevisiae); LENG5, leukocyte receptor cluster (LRC) member 5 , tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae); tRNA-splicing endonuclease subunit Sen34; SEN34; SEN34L; HsSen34; LENG 5; LENG5; Leukocyte receptor cluster (LRC) member 5; Leukocyte receptor cluster member 5; SEN 34; tRNA intron endonuclease Sen34; tRNA splicing endonuclease 34 homolog; tRNA splicing endonuclease subunit Sen34; TSEN 34; tRNA-intron endonuclease Sen34; PCH2C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSEN34-3444H Recombinant Human TSEN34, GST-tagged E.coli GST 1-390aa
Human TSEN34-721HCL Recombinant Human TSEN34 293 Cell Lysate HEK293 N/A
Human TSEN34-2800H Recombinant Human TSEN34 Protein, His-tagged E.coli His
Mouse TSEN34-17481M Recombinant Mouse TSEN34 Protein Mammalian Cell His
Mouse TSEN34-9669M Recombinant Mouse TSEN34 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TSEN34-9669M-B Recombinant Mouse TSEN34 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TSEN34-4990R Recombinant Rhesus monkey TSEN34 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TSEN34-4804R Recombinant Rhesus Macaque TSEN34 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TSEN34-4804R-B Recombinant Rhesus Macaque TSEN34 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TSEN34 Related Articles

TSEN34 involved in several pathways and played different roles in them. We selected most pathways TSEN34 participated on our site, such as Gene Expression, tRNA processing, tRNA processing in the nucleus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSEN34 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionSNAPC3;BRF1B;TBX5;ZNF566;SUPT4H1;GATAD2A;ARHGEF38;SF3B2;WTAP
tRNA processingRPP40;C2orf49;C14orf166;TSEN54;METTL1;ADAT3;RPP38;TYW3;MANEA
tRNA processing in the nucleusRPP38;TSEN15;ELAC2;XPOT;POP1;TSEN34;RPP14;ZBTB8OS;C14orf166

TSEN34 has several biochemical functions, for example, lyase activity, nucleic acid binding, tRNA-intron endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSEN34 itself. We selected most functions TSEN34 had, and list some proteins which have the same functions with TSEN34. You can find most of the proteins on our site.

Function Related Protein
lyase activityCar14;Car4;GC2;ACLYA;GUCY2E;CAR13;PTGESL;CBSB;NPR1A
nucleic acid bindingPUF60B;PRDM6;ZSCAN4C;SRSF2A;TRERF1;SP8A;IMPDH1;KLF5;PNMA3
tRNA-intron endonuclease activityTSEN15;TSEN34;TSEN2

TSEN34 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSEN34 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSEN34.

L1TD1; Batf3

Bierhals, T; Korenke, GC; et al. Pontocerebellar hypoplasia type 2 and TSEN2: Review of the literature and two novel mutations. EUROPEAN JOURNAL OF MEDICAL GENETICS 56:325-330(2013).
Cassandrini, D; Biancheri, R; et al. Pontocerebellar hypoplasia Clinical, pathologic, and genetic studies. NEUROLOGY 75:1459-1464(2010).
Graham, JM; Spencer, AH; et al. Molecular and Neuroimaging Findings in Pontocerebellar Hypoplasia Type 2 (PCH2): Is Prenatal Diagnosis Possible?. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:2268-2276(2010).
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