TSPAN8
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Official Full Name
tetraspanin 8
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Overview
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. -
Synonyms
TSPAN8; tetraspanin 8; TM4SF3, transmembrane 4 superfamily member 3; tetraspanin-8; CO 029; anti TSPAN8; CO029; TM4SF3; Transmembrane 4 superfamily member 3; Tspan 8; Tumor associated antigen CO 029; tspan-8; OTTHUMP00000241500; OTTHUMP00000241501; OTTHUMP00000241502; tumor-associated antigen CO-029; CO-029;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Canine
- Chicken
- Cynomolgus
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Mammalian Cell
- Fc|His
- His
- His (Fc)
- Avi
- N/A
- N
- mFc
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TSPAN8-917H | Active Recombinant Human TSPAN8 Full Length Transmembrane protein(Nanodisc) | HEK293 | N/A |
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| Human | TSPAN8-321H | Recombinant Human TSPAN8, Fc tagged | Human Cell | Fc/His |
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| Human | TSPAN8-400H | Recombinant Human TSPAN8, His tagged | Human Cell | N/A |
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| Human | TSPAN8-3461H | Recombinant Human TSPAN8, His-tagged | E.coli | His | 97-217aa | |
| Human | TSPAN8-997HCL | Recombinant Human TSPAN8 cell lysate | Human Cell | N/A |
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| Human | TSPAN8-1064HCL | Recombinant Human TSPAN8 cell lysate | Human Cell | N/A |
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| Human | TSPAN8-3251H | Recombinant Human TSPAN8 protein(Lys110-Asn205), mFc-tagged | HEK293 | N-mFc | Lys110-Asn205 |
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| Human | TSPAN8-1281H | Recombinant Human TSPAN8 protein, His-tagged | HEK293 | His | Lys110-Asn205 |
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| Mouse | TSPAN8-17517M | Recombinant Mouse TSPAN8 Protein | Mammalian Cell | His |
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| Mouse | TSPAN8-0745M | Recombinant Mouse TSPAN8 protein, His-tagged | HEK293 | His | Gly106-Asn203 |
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| Mouse | TSPAN8-9689M | Recombinant Mouse TSPAN8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | TSPAN8-9689M-B | Recombinant Mouse TSPAN8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bos taurus (Bovine) | RFL28123BF | Recombinant Full Length Bovine Tetraspanin-8(Tspan8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-238) |
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| Canine | TSPAN8-0746C | Recombinant Canine TSPAN8 protein, His-tagged | HEK293 | His | Lys110-His205 |
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| Cynomolgus | TSPAN8-0747C | Recombinant Cynomolgus TSPAN8 protein, His-tagged | HEK293 | His | Lys110-Ser205 |
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| Homo sapiens (Human) | RFL8945HF | Recombinant Full Length Human Tetraspanin-8(Tspan8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-237) |
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| Mus musculus (Mouse) | RFL15456MF | Recombinant Full Length Mouse Tetraspanin-8(Tspan8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-235) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL5677PF | Recombinant Full Length Pongo Abelii Tetraspanin-8(Tspan8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-237) |
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| Chicken | TSPAN8-4442C | Recombinant Chicken TSPAN8 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
TSPAN8 involved in several pathways and played different roles in them. We selected most pathways TSPAN8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TSPAN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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TSPAN8 has several biochemical functions, for example, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSPAN8 itself. We selected most functions TSPAN8 had, and list some proteins which have the same functions with TSPAN8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | JAM3;NIPAL1;ICAM1;ADAMTS5;VWF;NOV;CD151;ITGA6;SFRP2 |
TSPAN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSPAN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSPAN8.
- Q&As
- Reviews
Q&As (6)
Ask a questionDetecting the expression level of TSPAN8 protein can help with the diagnosis and prognosis of certain diseases. For example, in colon cancer patients, high expression of the TSPAN8 protein is often associated with malignancy and poor prognosis of the tumor.
The interaction of the TSPAN8 protein with other proteins plays an important role in a variety of diseases. For example, in colon cancer, the TSPAN8 protein can interact with integrins, promoting the proliferation and migration of tumor cells. Therefore, understanding these interactions is important for understanding the pathogenesis of disease and the selection of therapeutic targets.
With the in-depth understanding of the structure and function of TSPAN8 protein, the drug development and application of TSPAN8 protein will be more extensive in the future. For example, the development of drugs targeting the TSPAN8 protein may be used to treat tumors, autoimmune diseases, and neurological diseases.
There are a variety of polymorphisms in the TSPAN8 gene that may affect the structure and function of proteins and are associated with the development of certain diseases. For example, one study found that a polymorphism in the TSPAN8 gene was associated with susceptibility to esophageal cancer in northern Chinese populations.
Studies have shown that the TSPAN8 protein can participate in the apoptosis process. It can regulate the permeability of mitochondrial membranes by interacting with members of the Bcl-2 family, thereby influencing the conduction of apoptosis signals.
The activity of TSPAN8 protein is affected by a variety of regulators, including phosphorylation modification, ubiquitination modification, etc. These regulators can influence the structure and function of the TSPAN8 protein and thus its biological function.
Customer Reviews (3)
Write a reviewDue to wide range of applications of TSPAN8 is impressive, and no matter what field, it can play an important role.
Band position of TSPAN8 in Western blot was consistent with the expected, showing good target recognition ability.
The stability of TSPAN8 is excellent, and its performance remains stable after many repeated uses, showing good product quality.
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