TSPO
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Official Full Name
translocator protein (18kDa)
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Overview
Present mainly in the mitochondrial compartment of peripheral tissues, BZRP interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. -
Synonyms
TSPO; translocator protein (18kDa); benzodiazapine receptor (peripheral) , BZRP; translocator protein; DBI; IBP; MBR; mDRC; PBR; peripheral type benzodiazepine receptor/recognition site; pk18; PKBS; mitochondrial benzodiazepine receptor; benzodiazepine peripheral binding site; peripheral-type benzodiazepine receptor; PBS; BPBS; BZRP; PTBR;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pig
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- His|GST
- SUMO
- DDK
- MYC
- Myc|DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- TSPO Related Articles
TSPO involved in several pathways and played different roles in them. We selected most pathways TSPO participated on our site, such as Neuroactive ligand-receptor interaction, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neuroactive ligand-receptor interaction | TACR1;MC5RB;EDNRAA;TACR1A;GABRG3;GALR2;NMUR1;FPR2;TAAR7B |
HTLV-I infection | PDGFRB;NFATC4;HLA-DQA2;H2-AA;TRP53;H2-Q10;POLE2;MAP3K14;AKT1 |
TSPO has several biochemical functions, for example, androgen binding, benzodiazepine receptor activity, cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSPO itself. We selected most functions TSPO had, and list some proteins which have the same functions with TSPO. You can find most of the proteins on our site.
Function | Related Protein |
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androgen binding | SHBG;Ar;TSPO;ALDH1A1 |
benzodiazepine receptor activity | GABRA6;GABRA4;GABRG2;GABRA3;GABRA2;TSPO |
cholesterol binding | APOA1;NPC2;PROM2;APOA4B.2;NPC1;CETP;TSPO;APOEA;OSBP2 |
protein binding | ZIC3;JAKMIP1;SEPHS1;VLDLR;FGF3;RECQL;KIF3A;CX3CL1;PPP6R2 |
TSPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSPO here. Most of them are supplied by our site. Hope this information will be useful for your research of TSPO.
- Q&As
- Reviews
Q&As (6)
Ask a questionTSPO has an impact on neuroprotection by modulating mitochondrial function to affect the survival and death of nerve cells. Specific mechanisms include inhibition of apoptosis and alleviation of oxidative stress.
At present, the research on TSPO faces some challenges, such as the difference in the expression of TSPO in various tissues, the functional changes of TSPO in different disease states, and the interaction between TSPO and other molecules. However, with the continuous advancement of technology and the in-depth understanding of the functions of TSPO, it is expected that there will be greater breakthroughs in drug design and treatment strategies for TSPO in the future.
This protein regulates the permeability of mitochondrial membranes to cholesterol by binding to cholesterol transporters, thereby affecting cholesterol synthesis and trafficking.
Since TSPO is associated with a variety of diseases,it may be a therapeutic target for a variety of diseases, such as neurodegenerative diseases, cancer, and mental disorders. Some progress has been made in the design and development of drugs for TSPO.
Commonly used TSPO detection methods include immunohistochemistry, western blotting, flow cytometry, etc. In addition, TSPO ligands can also be used for binding experiments or functional experiments to study their biological functions.
The expression level of TSPO changes in a variety of physiological and pathological conditions, such as hypoxia, ischemia, inflammation, aging, etc. These changes affect the function of the mitochondria, which affects the survival and death of cells.
Customer Reviews (3)
Write a reviewProlonged transportation will not affect the stability of the product.
The price of this one is very reasonable, and the quality is very good, I am very satisfied.
It has high solubility and can be dissolved quickly.
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