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TSPO

  • Official Full Name

    translocator protein (18kDa)

  • Overview

    Present mainly in the mitochondrial compartment of peripheral tissues, BZRP interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis.
  • Synonyms

    TSPO; translocator protein (18kDa); benzodiazapine receptor (peripheral) , BZRP; translocator protein; DBI; IBP; MBR; mDRC; PBR; peripheral type benzodiazepine receptor/recognition site; pk18; PKBS; mitochondrial benzodiazepine receptor; benzodiazepine peripheral binding site; peripheral-type benzodiazepine receptor; PBS; BPBS; BZRP; PTBR;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • SUMO
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSPO-3462H Recombinant Human TSPO, His-tagged E.coli His 1-169aa
Human TSPO-1696H Recombinant Human TSPO protein, His & GST-tagged E.coli His/GST Met1~Glu169 (Accession # P30536)
Human TSPO-51H Recombinant Human TSPO, MYC/DDK-tagged HEK293 Myc/DDK
Human TSPO1-2961H Recombinant Human TSPO, T7-tagged E.coli T7
Human TSPO-703HCL Recombinant Human TSPO 293 Cell Lysate HEK293 N/A
Human TSPO-142HFL Active Recombinant Full Length Human TSPO Protein, C-Flag-tagged Mammalian cells Flag
Human TSPO-6213H Recombinant Human TSPO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TSPO-2267H-B Recombinant Human TSPO Protein Pre-coupled Magnetic Beads HEK293
Human TSPO-2267H Recombinant Human TSPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TSPO-17519M Recombinant Mouse TSPO Protein Mammalian Cell His
Mouse Tspo-2404M Recombinant Mouse Tspo Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-169aa
Mouse TSPO-9691M Recombinant Mouse TSPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TSPO-9691M-B Recombinant Mouse TSPO Protein Pre-coupled Magnetic Beads HEK293
Mouse Tspo-728M Recombinant Mouse Tspo Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat TSPO-6329R Recombinant Rat TSPO Protein Mammalian Cell His
Rat TSPO-5985R Recombinant Rat TSPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TSPO-5985R-B Recombinant Rat TSPO Protein Pre-coupled Magnetic Beads HEK293
Arabidopsis thaliana (Mouse-ear cress) RFL20879AF Recombinant Full Length Arabidopsis Thaliana Translocator Protein Homolog(Tspo) Protein, His-Tagged E.coli expression system His Full Length (1-196)
Bos taurus (Bovine) RFL12138BF Recombinant Full Length Bovine Translocator Protein(Tspo) Protein, His-Tagged E.coli expression system His Full Length (1-169)
Homo sapiens (Human) RFL9453HF Recombinant Full Length Human Translocator Protein(Tspo) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-169)
Mus musculus (Mouse) RFL17602MF Recombinant Full Length Mouse Translocator Protein(Tspo) Protein, His-Tagged E.coli expression system His Full Length (1-169aa)
Ovis aries (Sheep) RFL28585OF Recombinant Full Length Sheep Translocator Protein(Tspo) Protein, His-Tagged E.coli expression system His Full Length (1-169)
Rattus norvegicus (Rat) RFL9532RF Recombinant Full Length Rat Translocator Protein(Tspo) Protein, His-Tagged E.coli expression system His Full Length (1-169)
Rhesus Macaque TSPO-5005R Recombinant Rhesus monkey TSPO Protein, His-tagged Mammalian Cell His
Rhesus Macaque TSPO-4819R-B Recombinant Rhesus Macaque TSPO Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TSPO-4819R Recombinant Rhesus Macaque TSPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL35428SF Recombinant Full Length Pig Translocator Protein(Tspo) Protein, His&Myc-Tagged E.coli expression system His&Myc Full Length (1-169aa)
Zebrafish TSPO-1547Z Recombinant Zebrafish TSPO Mammalian Cell His
Pig TSPO-2722P Recombinant Pig TSPO Full Length Transmembrane protein (1-169 aa), His-SUMO-Myc-tagged In vitro E. coli expression system His-SUMO 1-169aa
Chicken TSPO-5333C Recombinant Chicken TSPO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TSPO Related Articles

TSPO involved in several pathways and played different roles in them. We selected most pathways TSPO participated on our site, such as Neuroactive ligand-receptor interaction, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionTACR1;MC5RB;EDNRAA;TACR1A;GABRG3;GALR2;NMUR1;FPR2;TAAR7B
HTLV-I infectionPDGFRB;NFATC4;HLA-DQA2;H2-AA;TRP53;H2-Q10;POLE2;MAP3K14;AKT1

TSPO has several biochemical functions, for example, androgen binding, benzodiazepine receptor activity, cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSPO itself. We selected most functions TSPO had, and list some proteins which have the same functions with TSPO. You can find most of the proteins on our site.

Function Related Protein
androgen bindingSHBG;Ar;TSPO;ALDH1A1
benzodiazepine receptor activityGABRA6;GABRA4;GABRG2;GABRA3;GABRA2;TSPO
cholesterol bindingAPOA1;NPC2;PROM2;APOA4B.2;NPC1;CETP;TSPO;APOEA;OSBP2
protein bindingZIC3;JAKMIP1;SEPHS1;VLDLR;FGF3;RECQL;KIF3A;CX3CL1;PPP6R2

TSPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSPO here. Most of them are supplied by our site. Hope this information will be useful for your research of TSPO.

Jensen, P; Kondziella, D; et al. Anti-NMDAR encephalitis Demonstration of neuroinflammation and the effect of immunotherapy. NEUROLOGY 84:859-859(2015).
Azarashvili, T; Baburina, Y; et al. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 558:87-94(2014).
  • Q&As
  • Reviews

Q&As (6)

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How does TSPO affect neuroprotection? 12/01/2022

TSPO has an impact on neuroprotection by modulating mitochondrial function to affect the survival and death of nerve cells. Specific mechanisms include inhibition of apoptosis and alleviation of oxidative stress.

What are the challenges and prospects of current research on TSPO? 05/23/2022

At present, the research on TSPO faces some challenges, such as the difference in the expression of TSPO in various tissues, the functional changes of TSPO in different disease states, and the interaction between TSPO and other molecules. However, with the continuous advancement of technology and the in-depth understanding of the functions of TSPO, it is expected that there will be greater breakthroughs in drug design and treatment strategies for TSPO in the future.

How is TSPO involved in the synthesis and transport of cholesterol? 04/25/2022

This protein regulates the permeability of mitochondrial membranes to cholesterol by binding to cholesterol transporters, thereby affecting cholesterol synthesis and trafficking.

Is TSPO associated with a variety of diseases, 10/29/2020

Since TSPO is associated with a variety of diseases,it may be a therapeutic target for a variety of diseases, such as neurodegenerative diseases, cancer, and mental disorders. Some progress has been made in the design and development of drugs for TSPO.

How to detect the expression and function of TSPO? 04/18/2020

Commonly used TSPO detection methods include immunohistochemistry, western blotting, flow cytometry, etc. In addition, TSPO ligands can also be used for binding experiments or functional experiments to study their biological functions.

What circumstances does the expression level of TSPO change? 04/07/2020

The expression level of TSPO changes in a variety of physiological and pathological conditions, such as hypoxia, ischemia, inflammation, aging, etc. These changes affect the function of the mitochondria, which affects the survival and death of cells.

Customer Reviews (3)

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Reviews
01/28/2023

    Prolonged transportation will not affect the stability of the product.

    07/11/2021

      The price of this one is very reasonable, and the quality is very good, I am very satisfied.

      02/13/2020

        It has high solubility and can be dissolved quickly.

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