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TTF2

Official Full Name

transcription termination factor, RNA polymerase II
Overview

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
Synonyms

TTF2; transcription termination factor, RNA polymerase II; transcription termination factor 2; HuF2; F2; human factor 2; lodestar homolog; lodestar protein; transcription release factor 2; RNA polymerase II termination factor;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TTF2-3478H	Recombinant Human TTF2, GST-tagged	E.coli	GST	1-300aa	$319 / 25ug
Mouse	TTF2-17583M	Recombinant Mouse TTF2 Protein	Mammalian Cell	His		Inquiry
Mouse	TTF2-9733M	Recombinant Mouse TTF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TTF2-9733M-B	Recombinant Mouse TTF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

TTF2 involved in several pathways and played different roles in them. We selected most pathways TTF2 participated on our site, such as Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone synthesis	LRP2;PRKCA;SLC26A4;DUOX2;GPX2;IYD;PRKCG;PRKCB;PRKACB

TTF2 has several biochemical functions, for example, ATP binding, ATP-dependent helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTF2 itself. We selected most functions TTF2 had, and list some proteins which have the same functions with TTF2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	RUNX2B;RBM4.3;PIP5KL1;HSPA1L;DDX41;ATP6V1B1;YME1L1B;CAMKV;HSPA7
ATP-dependent helicase activity	ERCC6L2;BLM;SNRNP200;DHX36;RECQL5;RTEL1;TTF2;DHX37;CHD4A
DNA binding	ZBTB26;MBD1B;DDX41;IRF6;TFDP3;ZNF496;RFX8;ZNF576.2;AHR
DNA-dependent ATPase activity	MSH6;SMARCAL1;MSH3;SMARCA4;MSH5;CHD6;CHD8;SMARCA2;XRCC2
protein binding	WDYHV1;ATF1;USP44;INSIG1;SSBP3;IL-8;BCL7B;TOR1AIP2;ARHGAP44
zinc ion binding	TRIM45;CAD;PPARAB;PHF13;NR6A1A;ALAD;IGHMBP2;SIAH1A;BFAR

TTF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TTF2.

CDC5L; SIRT3; SMAD7; NVL; MYBL2; SKIL; PRDX4; DRAP1; TNIP1; SMAD1; CDKL3; PDCD6IP; CLPB; DCP1A; TACC3; mdm2_human_probe