TUBG1
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Official Full Name
tubulin, gamma 1
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Synonyms
TUBG1; tubulin, gamma 1; TUBG, tubulin, gamma polypeptide; tubulin gamma-1 chain; TUBGCP1; gamma-1-tubulin; tubulin, gamma polypeptide; gamma-tubulin complex component 1; TUBG; GCP-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TUBG1 involved in several pathways and played different roles in them. We selected most pathways TUBG1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | CEP290;CEP152;CLASP1A;NPHP4;CSNK1D;NEDD1;CP110;DCTN2;CEP63 |
| Assembly of the primary cilium | CEP78;SSNA1;C11orf60;ARL3;BBS12;BBS7;CEP89;FBF1;TMEM216 |
| Cell Cycle | HDAC5;E2F4;BRCC3;PSMC3IP;CDC27;CP110;TRP53;YWHAQB;PHF8 |
| Cell Cycle, Mitotic | CEP164;MAU2;DHFR;CLASP1A;NEK9;NUPL2;CDKN2B;TUBG1;RCC2 |
| Centrosome maturation | PLK4;TSGA14;CEP57;CDK11B;CCP110;DYNC1I2;OFD1;TUBG1;DCTN2 |
| G2/M Transition | CEP76;TUBGCP4;CENPJ;TUBGCP5;NEDD1;MAPRE1;CEP152;FOXM1;DYNC1H1 |
| Loss of Nlp from mitotic centrosomes | CP110;CKAP5;CEP70;TUBG1;CEP152;ODF2B;ODF2;CEP290;SDCCAG8 |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | ODF2;DCTN1A;CEP78;CEP135;ODF2B;CEP70;CEP164;CEP57;MAPRE1 |
TUBG1 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBG1 itself. We selected most functions TUBG1 had, and list some proteins which have the same functions with TUBG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAC1A;TUBA4L;ACSM1;EEF1A1L1;RAB15;RAB3DB;RRAGB;SRP54;RAB35B |
| GTPase activity | TUBB4B;DNM2B;RAB33A;EEFSEC;RAB23;RAB4A;RAB32A;ARHGDIB;RAB40B |
| protein binding | LAMA1;CPEB4;ZMYND19;APPBP2;RNF144B;MAGEB2;FAM82A2;EFNA3;HER5 |
| structural constituent of cytoskeleton | SPTBN2;DES;TLN2A;CCDC6;ACTL6B;SORBS3;BICD1;F-KER;ACTA1 |
TUBG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBG1.
MZT1; MARK4; Mzt2; TUBGCP3; AXIN1; MZT2B; DISC1; Tubgcp3
- Q&As
- Reviews
Q&As (6)
Ask a questionThere are still some limitations in the current research on TUBG1, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since TUBG1 is an important component of the cytoskeleton, its regulation may also have some side effects.
Studies have shown that the expression level of TUBG1 is associated with some neurological diseases. For example, in the brains of patients with Alzheimer's disease (AD), the expression levels of TUBG1 are downregulated, which can lead to neuronal damage and death. In some tumors, the expression level of TUBG1 is upregulated, which may promote the proliferation and metastasis of tumor cells.
The expression level of TUBG1 can be detected by immunohistochemistry, western blotting, real-time PCR and other methods. These methods can detect protein or mRNA levels of TUBG1 in tissues or cells to assess changes in its expression in disease.
Recent studies have found that TUBG1 is also involved in cell cycle regulation and DNA repair processes. These processes have an important impact on the survival and death of cells, and also provide new ideas for the treatment of some diseases related to TUBG1.
Therapeutic strategies for TUBG1 include modulating its expression levels, inhibiting its activity, or using gene therapy. For example, some studies have shown that the use of microtubule stabilizers can increase the expression level and activity of TUBG1, thereby treating some TUBG1-related neurological diseases.
TUBG1 has complex relationships with other genes or proteins. For example, it interacts with other members of the tubulin family to form microtubules. In addition, TUBG1 is regulated by a number of transcription factors and signal transduction pathways.
Customer Reviews (3)
Write a reviewThe activity is strong, and the experimental effect is obvious.
Enzyme activity and receptor binding activity are very good.
The consistency is good, and the results of multiple experiments are highly reproducible.
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