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TWIST1

  • Official Full Name

    twist homolog 1 (Drosophila)

  • Overview

    Twist1 is the basic helix-loop-helix transcription factor that regulates embryonic progenitor and transformed tumor cell proliferation, migration and differentiation and is also important in limb development. It has been shown that twist1 expression is high in patients suffering from rheumatic inflammatory disorders with chronically activated T helper lymphocytes and may be used as a biomarker for chronic t-cell activation. Mutations in twist1 are often associated with craniofacial and limb abnormalities in humans with Saethre-Chotzen syndrome. Twist1 dimer affinity can modify the DNA binding affinity. Twist1 has also been implicated as a promoter of tumor growth,Invasion and anti-cancer-drug resistance.
  • Synonyms

    TWIST1; twist homolog 1 (Drosophila); acrocephalosyndactyly 3 , ACS3, blepharophimosis, epicanthus inversus and ptosis 3 , BPES3, TWIST; twist-related protein 1; bHLHa38; BPES2; H twist; Saethre Chotzen syndrome; SCS; H-twist; B-HLH DNA binding protein; TWIST homolog of drosophila; class A basic helix-loop-helix protein 38; ACS3; CRS1; BPES3; TWIST;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TWIST1-3494H Recombinant Human TWIST1, GST-tagged E.coli GST 1-202aa
Human TWIST1-1865HCL Recombinant Human TWIST1 cell lysate N/A
Human TWIST1-2621H Recombinant Human TWIST1 protein, His-tagged E.coli His 12-72 aa
Human TWIST1-2973H Recombinant Human TWIST1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TWIST1-2100HFL Recombinant Full Length Human TWIST1 Protein, C-Flag-tagged Mammalian cells Flag
Human TWIST1-2280H Recombinant Human TWIST1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TWIST1-511H Recombinant Human TWIST1 Protein, His-tagged E.coli N-His Ser102-His202
Human TWIST1-6521H Recombinant Human TWIST1 Protein E.coli Tag Free
Human TWIST1-2280H-B Recombinant Human TWIST1 Protein Pre-coupled Magnetic Beads HEK293
Human TWIST1-6522H Recombinant Human TWIST1 Protein (Met1-His202), N-His tagged E.coli N-His Met1-His202
Human TWIST1-512H Recombinant Human TWIST1 Protein, His&GST-tagged E.coli N-His&GST Met1-His202
Mouse TWIST1-17644M Recombinant Mouse TWIST1 Protein Mammalian Cell His
Mouse Twist1-6740M Recombinant Mouse Twist1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TWIST1-9779M Recombinant Mouse TWIST1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TWIST1-9779M-B Recombinant Mouse TWIST1 Protein Pre-coupled Magnetic Beads HEK293
Chicken TWIST1-6304C Recombinant Chicken TWIST1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TWIST1 Related Articles

TWIST1 involved in several pathways and played different roles in them. We selected most pathways TWIST1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TWIST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerESR1;PTK2;TRP53;PPP1R12C;WNT3;PRKCG;RPS6;PPP1CB;WNT11

TWIST1 has several biochemical functions, for example, E-box binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TWIST1 itself. We selected most functions TWIST1 had, and list some proteins which have the same functions with TWIST1. You can find most of the proteins on our site.

Function Related Protein
E-box bindingNEUROD2;ASCL2;C1orf51;ASCL1;BHLHE40;TFAP4;GATA3;TAL1;LMO2
RNA polymerase II transcription factor activity, sequence-specific DNA bindingBHLHE40;FOXJ3;ZSCAN1;TFAP2B;FOXD1L;JUNBA;JUND;PLAG1;TAL2
bHLH transcription factor bindingTCF3;USF2;SOX9;HAND1;SP1;MAP3K10;RUNX2;ASCL1;TCF3A
protein bindingBRPF3;TMEM43;NDUFA9;RGR;ASB3;NFKB1;SSBP1;GDF5;DHX9
protein domain specific bindingICA1;CHMP1A;ITGA3;WNT5A;RAB27B;YWHAZ;SHROOM2;STXBP1;STMN3
protein heterodimerization activityITGB1B;TAF4B;TENM1;UGT1A7;HIST1H4H;UGT1A3;OSTB;HIST2H2BE;BDKRB2
protein homodimerization activityDMRT2;KYNU;NPM1;CPNE1;ADRB3;GDF6;RABEP1;ASGR1;ANXA1
transcription factor bindingCSNK2B;HDAC1;SMAD3;BCL3;PITX2;PPP1R13BB;TFAP2A;HTT;ATF7

TWIST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TWIST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TWIST1.

TP53; HIST2H4B; SETD8

Song, H; Kim, TO; et al. Intratumoral heterogeneity impacts the response to anti-neu antibody therapy. BMC CANCER 14:-(2014).
Gilje, B; Nordgard, O; et al. Comparison of molecular and immunocytochemical methods for detection of disseminated tumor cells in bone marrow from early breast cancer patients. BMC CANCER 14:-(2014).
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