TAB3
-
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 3
-
Overview
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; MAP3K7IP3, mitogen activated protein kinase kinase kinase 7 interacting protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAK1 binding protein 3; TAB-3; TAK1-binding protein 3;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | TAB3-4149Z | Recombinant Zebrafish TAB3 | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- TAB3 Related Articles
TAB3 involved in several pathways and played different roles in them. We selected most pathways TAB3 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | HSP90B1;CARD8;Ccl12;MAPK10;NAIP1;RELA;NAIP6;NAIP7;NLRP3 |
TAB3 has several biochemical functions, for example, kinase activity, transferase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB3 itself. We selected most functions TAB3 had, and list some proteins which have the same functions with TAB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | HMGXB3;NME2A;CKMT2A;CAMK2N1A;PRKCDA;TNIKA;RAF1B;CCNE1;cka1 |
| transferase activity | UGT5B3;TRMT12;CHST2;PRKCHA;HS6ST1A;IGF1RA;SPTLC2B;cka1;SULT1ST5 |
| zinc ion binding | ZNRF2A;ZDHHC9;RNF187;ZDHHC16B;MIB1;MLLT10;MTA2;NEURL3;SOD1 |
TAB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAB3.
- Q&As
- Reviews
Ask a Question for All TAB3 Products
Required fields are marked with *
My Review for All TAB3 Products
Required fields are marked with *
