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TAP2

Official Full Name

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Overview

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
Synonyms

TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); APT2; PSF2; ABC18; ABCB3; RING11; D6S217E; antigen peptide transporter 2; PSF-2; OTTHUMP00000029078; OTTHUMP00000218770; ABC transporter, MHC 2; peptide supply factor 2; peptide transporter TAP2; really interesting new gene 11 protein; peptide transporter involved in antigen processing 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
E.Coli or Yeast
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAP2-7880H	Recombinant Human TAP2 protein, His & T7-tagged	E.coli	His/T7	Val468~Leu686 (Accession # Q03519)	Inquiry
Human	TAP2-1736HCL	Recombinant Human TAP2 cell lysate		N/A		Inquiry
Human	TAP2-660H	Recombinant Human TAP2 Protein, GST-tagged	Wheat Germ	GST	1-686 aa	Inquiry
Human	TAP2-6806HF	Recombinant Full Length Human TAP2 Protein, GST-tagged	In Vitro Cell Free System	GST	686 amino acids	Inquiry
Mouse	TAP2-16421M	Recombinant Mouse TAP2 Protein	Mammalian Cell	His		Inquiry
Mouse	TAP2-8986M	Recombinant Mouse TAP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TAP2-8986M-B	Recombinant Mouse TAP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Tap2-3513R	Recombinant Rat Tap2, His-tagged	E.Coli or Yeast	His	703	Inquiry
Rat	TAP2-5927R	Recombinant Rat TAP2 Protein	Mammalian Cell	His		Inquiry
Rat	Tap2-7881R	Recombinant Rat Tap2 protein, His & T7-tagged	E.coli	His/T7	Arg467~Ala7036 (Accession # P36372)	Inquiry
Rat	TAP2-5586R	Recombinant Rat TAP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TAP2-5586R-B	Recombinant Rat TAP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	TAP2-3722C	Recombinant Chicken TAP2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAP2 Related Articles

TAP2 involved in several pathways and played different roles in them. We selected most pathways TAP2 participated on our site, such as ABC transporters, Phagosome, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ABC transporters	ABCA4;ABCB6A;ABCA9;ABCD3A;ABCG3;ABCB4;Abcb1b;ABCB5;ABCB10
Phagosome	ITGAV;FCGR2B;MHC2DCB;ACTG1;HBL4;DYNC1LI1;ITGB1;ATP6AP1B;TFR1A
Antigen processing and presentation	HLA-DRB4;TAP2;CALR;IFI30;HLA-DOB;CD8A;CANX;KIR3DL2;TAP1
Herpes simplex infection	TAF6;TAF10;IRF3;HLA-DQA1;CASP3A;IFNA3;CLOCK;CFP;IFNB1
Primary i	CD8B;RAG1;BTK;IL7R;LCK;BLNK;RFX5;CD3D;ZAP70
nodeficiency	CD40LG;RFXAP;IL7R;LCK;IKBKG;RFXANK;PTPRC;TNFRSF13B;TAP2

TAP2 has several biochemical functions, for example, ATP binding, MHC class Ib protein binding, TAP1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAP2 itself. We selected most functions TAP2 had, and list some proteins which have the same functions with TAP2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CLK1;ABCB6;MAP3K2;CAMKK1B;UBE2H;CDK11A;PDK3;CARNS1;STK25
MHC class Ib protein binding	LILRB2;TAP2;TAP1
TAP1 binding	HLA-F;TAP1;TAP2;TAPBP
peptide antigen-transporting ATPase activity	TAP2;TAPBP
contributes_to peptide transporter activity	TAP2;TAP1
protein binding	MSR1;DOCK4;ABCG1;LDB3;HIST1H3A;UHRF1;UBE2E2;UBE2D3;STAMBP
tapasin binding	TAP1;TAP2
transporter activity	NUP155;CRABP1B;FABP1B.1;TMEM184BA;ATP5D;RBP2;GABRA5;SLCO1D1;PTGDS

TAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAP2.

TAP1; TAPBP

Niu, G; Ma, J; et al. The Hierarchical Importance of Components of The Peptide-loading Complex. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41:904-915(2014).

Tuncel, J; Haag, S; et al. Natural Polymorphisms in Tap2 Influence Negative Selection and CD4 : CD8 Lineage Commitment in the Rat. PLOS GENETICS 10:-(2014).