TDGF1
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Official Full Name
teratocarcinoma-derived growth factor 1
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Overview
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] -
Synonyms
TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- Human
- Human Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- C
- Fc
- hFc
- His
- GST
- His(C
- ter)
- human|IgG1|Fc
- MBP
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- TDGF1 Related Research Area
TDGF1 involved in several pathways and played different roles in them. We selected most pathways TDGF1 participated on our site, such as Developmental Biology, Glypican 1 network, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | EGR2;TCF3A;SALL4;TRPC3;RND1L;UNC5D;DPYSL5A;MED25;LAMTOR2 |
| Glypican 1 network | |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | NR6A1;TDGF1;FOXD3 |
| Regulation of signaling by NODAL | TDGF1;ACVR1C;LEFTY1;CFC1 |
| Signaling by NODAL | LEFTY1;TDGF1;CFC1;PCSK6;FOXH1;ACVR1C;GDF1;DRAP1 |
| Transcriptional regulation of pluripotent stem cells | POU5F3;NR6A1;TDGF1;FOXD3;PRDM14;LIN28A;HIF3A;NR5A1;SALL4 |
TDGF1 has several biochemical functions, for example, growth factor activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDGF1 itself. We selected most functions TDGF1 had, and list some proteins which have the same functions with TDGF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | IL3;FGF18A;RABEP2;CSF3;MDKA;FGF8B;FIGF;NENF;BMP8A |
| protein binding | RAD51C;OBFC2B;SMAD1;HSPA13;KLK4;RIPPLY3;LRRFIP2;BIRC7;C22orf29 |
| receptor binding | PIPOX;TENC1;HCK;GNB2L1;AKAP9;HFE;CRH;DVL3;ENSA |
TDGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDGF1.
GPC1; GDF9; ANG; FBLN1; BAG6; AP2S1; RIF1; COPS6; FARSA
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in the TDGF1 gene have been linked to certain congenital disorders. Understanding these genetic associations can provide insights into the underlying mechanisms of these conditions.
TDGF1 has been found to play a role in neural development. It is involved in the specification of neural cell fate and the formation of the neural tube during embryogenesis.
Yes, efforts are underway to develop drugs that modulate TDGF1 activity. Targeting TDGF1 could potentially lead to novel therapies for conditions related to cell growth and differentiation.
TDGF1 is involved in the maintenance of pluripotency in embryonic stem cells. Understanding its role could enhance our ability to control and manipulate stem cells for therapeutic purposes.
Researchers are exploring the use of TDGF1 as a biomarker for certain cancers. Detection of elevated TDGF1 levels in patient samples may aid in early cancer diagnosis.
Customer Reviews (3)
Write a reviewthe manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of TDGF1 protein in trials.
manufacturers often have a wealth of knowledge and expertise in the field of TDGF1 protein research.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of TDGF1 protein in their studies.
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