tek
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  • Official Full Name
  • TEK tyrosine kinase, endothelial
  • Background
  • This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
  • Synonyms
  • TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; venous malformations, multiple cutaneous and mucosal; Angiopoietin-1 receptor; EC=2.7.10.1; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; OTTHUMP00000021167; OTTHUMP00000227067; OTTHUMP00000227068; OTTHUMP00000227069; soluble TIE2 variant 1; soluble TIE2 variant 2
Cat.#:TEK-2054HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TEK Protein, Fc/His-tagged
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Cat.#:TEK-1687HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial
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Cat.#:TEK-445HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial, GST-tagged, Active
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Cat.#:TEK-547HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial, His-tagged
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Cat.#:TEK-75HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial, Fc-tagged
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Cat.#:Tek-1779MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Endothelial-specific Receptor Tyrosine Kinase
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Cat.#:Tek-89MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Tek, Fc-tagged
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Cat.#:TEK-153HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TEK, Fc-His tagged
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Cat.#:TEK-154HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TEK, His tagged
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Cat.#:TEK-17HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (R849W), GST-tagged
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Cat.#:TEK-18HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (P883A), GST-tagged
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Cat.#:TEK-19HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (Y897C), GST-tagged
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Cat.#:TEK-20HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (Y897S), GST-tagged
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Cat.#:TEK-21HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (Y1108F), GST-tagged
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Cat.#:TEK-22HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIE2 (A1124V), GST-tagged
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Cat.#:TEK-30629THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TEK, Fc-tagged
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Cat.#:TEK-31525THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TEK, His-tagged
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Cat.#:TEK-3177HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TEK, GST-tagged
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Cat.#:TEK-39HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TEK protein, GST-tagged
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Cat.#:TEK-40HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TEK protein, GST-tagged
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Cat.#:TEK-41HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TEK protein, GST-tagged
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Cat.#:TEK-42HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TEK protein, GST-tagged
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Cat.#:TEK-469HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TEK
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Cat.#:TEK-535HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TEK protein, His & T7-tagged
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Cat.#:TEK-585HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TEK Protein, DDK/His-tagged
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Cat.#:TEK-702HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TEK, Fc-tagged, Biotinylated
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Cat.#:TEK-703HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TEK, Fc-tagged
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Cat.#:TEK-7296HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TEK, His & GST tagged
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Cat.#:TEK-84HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TEK protein, Flag-tagged, Biotinylated
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Cat.#:Tek-490MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Tek, Fc Chimera
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Cat.#:Tek-73MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Tek protein, His-tagged
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Cat.#:Tek-7418MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tek, His tagged
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Cat.#:Tek-7419MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Tek, His & GST tagged
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Cat.#:Tek-959MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tek Protein, Fc-tagged
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Cat.#:Tek-1360RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tek, Fc tagged
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Cat.#:Tek-537RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tek protein, His & GST-tagged
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Cat.#:Tek-675RTag:Fc Chimera
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Tek, Fc Chimera
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Cat.#:TEK-155CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TEK, Fc tagged
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Cat.#:TEK-212CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TEK, Fc-tagged
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Cat.#:tek-1020ZTag:Fc
Source (Host):NSO CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish tek Protein, Fc Chimera
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Cat.#:TEK-9028ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TEK
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Cat.#:TEK-390HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial, His-tagged
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Cat.#:TEK-1311HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TEK Tyrosine Kinase, Endothelial
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Cat.#:TEK-415HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TEK cell lysate
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Cat.#:TEK-1511MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TEK cell lysate
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Cat.#:TEK-404MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse TEK cell lysate
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Cat.#:TEK-1707RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TEK cell lysate
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Cat.#:TEK-1065CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TEK cell lysate
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Involved Pathway

Tek involved in several pathways and played different roles in them. We selected most pathways Tek participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tek were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RAP1B; HRAS; PDGFD; FGF12; CALM4; TBK1; PLA2G4F; CALML3; PIK3R5; GRB2
Rap signaling pathway
RALGDS; FGFR4; FGF13; KRIT1; RASGRP3; MAP2K2; PLCG1; CALM2; LAT; PIK3R1
HIF- signaling pathway
ENO3; LTBR; PDK1; RBX1; INS1; MAP2K2; LDHA; AKT2; HIF1A; INSR
PIK-Akt signaling pathway
PRKAA1; GNB1; THBS2; Kitl; KITLG; ITGB5; MAPK3; PKN2; FGF22; NR4A1
Rheumatoid arthritis
Ccl12; HLA-DOB; MMP1; IL1B; CD86; TGFB1; IL11; ATP6V1F; CCL5; ICAM1

Protein Function

Tek has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tek itself. We selected most functions Tek had, and list some proteins which have the same functions with Tek. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CAMK1DA; PIP5KL1; VSIG8B; CAMK1GA; NME3; UBE2Q2; LACE1A; DDX10; UBE2I; AAK1
Function growth factor binding
Related Protein FLT4; SDCBP; REG3B; GHRHR; GHR; IGFBP2B; TEK; LTBP4; HTRA1A; IL6ST
Function protein binding
Related Protein CTLA4; OLFM1; POC5; PRKAA2; UBASH3A; MARCKSL1; MC2R; KDRL; OSGIN1; FCER1G
Function protein kinase activity
Related Protein PDK2; CCL2; RPS6KA3; MAP3K11; CCND1; FYNB; NLK1; STK3; SBK1; STK26
Function protein tyrosine kinase activity
Related Protein PTK7A; TYRO3; PTK2B; DYRK1A; MATK; JAK3; MAP2K6; INSR; KIT; FYNA
Function receptor activity
Related Protein TLR3; RTN4R; MED14; CD200; TLR6; RTN4RL2; ICAM1; TLR4; PVRL1B; ADCYAP1R1
Function transmembrane receptor protein tyrosine kinase activity
Related Protein NPTNB; TIE1; EGFRA; EGFR; KDRL; EPHA4A; CADM2B; EPHB4A; ALK; TYRO3

Interacting Protein

Tek has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tek here. Most of them are supplied by our site. Hope this information will be useful for your research of Tek.
ANGPT2; SHC1; Angpt2; PTPRC; PKM; PTPRB; PTPRG; PTPN12; PTPRJ; PTPRK

Tek Related Articles

Chen, JY; Liu, ZJ; et al. Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells. PLOS ONE 9:-(2014).
Kobayashi, M; Shelley, WC; et al. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf beta for their development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:12151-12156(2014).