TGFBR3
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Official Full Name
transforming growth factor, beta receptor III
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Overview
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
TGFBR3; transforming growth factor, beta receptor III; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor beta receptor type 3; betaglycan; betaglycan proteoglycan; BGCAN; TGFR-3; TGF-beta receptor type 3; TGF-b;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- His
- His (Fc)
- Avi
- His|GST
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TGFBR3 Related Gene Family
- TGFBR3 Related Research Area
- TGFBR3 Related Signal Pathway
TGFBR3 involved in several pathways and played different roles in them. We selected most pathways TGFBR3 participated on our site, such as TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, TGF-beta receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF Beta Signaling Pathway | ZFP423;NOG;RUNX3;FOXH1;ZNF423;FST;TGFBR3;ENG;LEFTY1 |
| TGF-beta Receptor Signaling Pathway | SKIA;STAMBPL1;NFYBB;DAB2;GIPC1;STRAP;TRAP1;EID2;HOXD9A |
| TGF-beta receptor signaling | STRAP;EIF2A;TGFBR3;DAB2 |
TGFBR3 has several biochemical functions, for example, PDZ domain binding, SMAD binding, activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR3 itself. We selected most functions TGFBR3 had, and list some proteins which have the same functions with TGFBR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | KIDINS220B;ATP2B4;LRP2;SNTB1;F11R;ACCN3;NSF;LIN7C;SRR |
| SMAD binding | SKILB;SMURF2;STUB1;PURB;COL1A2;TOB1;SOD3;ACVR1;ACVRL1 |
| activin binding | FSTL3;ACVR2B;ENG;FST;TGFBR3;ACVR1;ACVRL1;SMURF1;SMAD7 |
| coreceptor activity | RGMD;TGFBR3;ACVR2A;LY96;CD8A;CCR5;CXCR7;CD8B;CD86 |
| fibroblast growth factor binding | FGFBP3;THBS1;FGFBP1;RPS19;FGFRL1;GLG1B;SCN5A;FIBPA;CEP57 |
| glycosaminoglycan binding | SERPINA5;EGFLAM;VCAN;VIT;ENG;TGFBR2;PODXL2;NDNF;DCN |
| heparin binding | FGF2;FSTL1;APP;FGF10;ZNF146;THBS4;APLP1;CYR61L1;COMP |
| protein binding | CDK5RAP3;ARL2BP;ERP29;SLC25A5;ZP3;LMX1B;C6orf108;PRKCE;LLGL1 |
| contributes_to protein binding | MEF2A;TGFBR3;PAK1;CRY1A;MSH2;TAF10;MSH6;INHA;POLR2A |
| transforming growth factor beta binding | LTBP1;TGFBR2;CD109;TGFBR1;ITGAV;ENG;VASN;TGFBR3;THBS1 |
| contributes_to transforming growth factor beta binding | TGFBR2;TGFBR3;TGFBR1;ENG |
| transforming growth factor beta receptor activity, type III | |
| transforming growth factor beta receptor binding | LEFTY1;BMP7B;GDF11;SMAD3;GDF10;FKBP1A;GDF3;AMH;TGFBR3 |
| transforming growth factor beta-activated receptor activity | LTBP1;TGFBR2;ACVRL1;TGFBR1;BMPR2A;TGFBR3;BMPR2B;ENG |
| type II transforming growth factor beta receptor binding | BAMBI;TGFB1;TGFBR1;TGFBR3;TGFB2;ENG;TGFB3;TGFB1A |
TGFBR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR3.
GIPC1; TGFB1; TGFB3; cutF
- Q&As
- Reviews
Q&As (5)
Ask a questionTGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.
TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.
TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.
TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.
TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.
Customer Reviews (3)
Write a reviewGreat product !
Seamless delivery process—ordered, received, and ready for experiments.
Timely delivery is key, and this product arrived on schedule.
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