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THPO

  • Official Full Name

    thrombopoietin

  • Overview

    Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5 UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
  • Synonyms

    THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Therapeutic Proteins
  • Bovine
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Porcine
  • Rat
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Yeast
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His(N
  • ter)
  • His|GST
  • His|T7
  • SUMO
  • N/A
  • N
  • MBP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human THPO-82H Active Recombinant Human Thrombopoietin HEK293 N/A
Human THPO-216H Active Recombinant Human THPO Protein, His-tagged HEK293 His
Human THPO-269H Active Recombinant Human Thrombopoietin Human N/A
Human THPO-861H Active Recombinant Human THPO, His tagged CHO His Met 1-Gly 353
Human THPO-27H Active Recombinant Human Thrombopoietin HEK293 N/A
Human THPO-216HB Active Recombinant Human THPO protein, His-tagged, Biotinylated HEK293 His
Human THPO-573H Recombinant Human THPO protein, His & GST-tagged E.coli His/GST Ser22~Gly349
Human THPO-176H Recombinant Human Thrombopoietin Mammalian cells N/A
Human THPO-26H Recombinant Human Thrombopoietin Mammalian Cell N/A
Human THPO-98H Recombinant Human Thrombopoietin, His-tagged HEK293 His
Human THPO-29520TH Recombinant Human THPO E.coli N/A 174 amino acids
Human THPO-175H Recombinant Human Thrombopoietin Sf21 Insect Cell N/A
Human THPO-81H Recombinant Human THPO, Fc-tagged Human Cell Fc
Human THPO-80H Recombinant Human THPO, His-tagged Human Cell His
Human THPO-1533H Recombinant Human Thrombopoietin HEK293 N/A
Human THPO-99H Recombinant Human THPO protein, His-tagged HEK293 His Met1-Gly353
Human THPO-001HCL Recombinant Human THPO cell lysate CHO N/A
Human THPO-2832HCL Recombinant Human THPO cell lysate Human Cell N/A
Human THPO-3577H Recombinant Human THPO protein, His-SUMO-tagged E.coli His-SUMO 22-195aa
Human THPO-13H Recombinant Human Thrombopoietin Reference standard N/A
Human THPO-01H Active Recombinant Human THPO Protein, His-tagged HEK293 His
Human THPO-41HG Recombinant Human THPO Protein, GMP Grade, Animal-Free E.coli
Human THPO-305H Recombinant Active Human THPO Protein, His-tagged(N-ter) E.coli His(N-ter)
Human THPO-12HG Active Recombinant Human THPO Protein (Ser22-Leu195), GMP Grade, Animal-Free E.coli Ser22-Leu195
Human THPO-432HG Active GMP Recombinant Human THPO protein, Fc-tagged HEK293 Fc DNA sequence encoding Human TPO(NP_000451.1) was expressed with Fc tag at the C-terminal.
Human THPO-0750H Active Recombinant Human THPO protein HEK293 N/A Ser22-Gly353
Human THPO-289H Recombinant Human THPO Protein (Ser22-Leu195), N-His tagged, Animal-free, Carrier-free E.coli N-His Ser22-Leu195
Human THPO-4490H Recombinant Human THPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human THPO-5481H Recombinant Human THPO Protein (Pro25-His298), GST tagged E.coli GST Pro25-His298
Human THPO-2753H Recombinant Human THPO protein(22-353 aa), N-SUMO & C-His-tagged E. coli N-SUMO & C-His 22-353 aa
Human THPO-5482H Recombinant Human THPO Protein (Ser22-Gly353), C-His tagged Mammalian cells C-His Ser22-Gly353
Human THPO-4490H-B Recombinant Human THPO Protein Pre-coupled Magnetic Beads HEK293
Human THPO-5483H Recombinant Human THPO Protein (Pro25-His294), N-GST tagged E.coli N-GST Pro25-His294
Human THPO-2754H Recombinant Human THPO protein(22-353 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 22-353 aa
Human THPO-P02H Recombinant Human THPO, Fc-tagged therapeutic protein E.coli Fc
Human THPO-2755H Recombinant Human THPO protein(22-353 aa), N-SUMO & N-His-tagged HEK293 N-SUMO & N-His 22-353 aa
Human THPO-2752H Recombinant Human THPO protein(22-353 aa), N-MBP & C-His-tagged E. coli N-MBP & C-His 22-353 aa
Mouse Thpo-177M Recombinant Mouse Thrombopoietin Mammalian cells N/A
Mouse Thpo-1782M Recombinant Mouse Thrombopoietin, Fc Chimera Mammalian cells Fc
Mouse Thpo-97M Active Recombinant Mouse Thpo protein, His-tagged HEK293 His Met1-Thr356
Mouse Thpo-1531M Recombinant Mouse Thpo protein E.coli N/A 174
Mouse THPO-2831MCL Recombinant Mouse THPO cell lysate Human Cell N/A
Mouse Thpo-6417M Active Recombinant Mouse Thpo Protein CHO Ser22-Thr356
Mouse Thpo-895M Recombinant Mouse Thpo Protein CHO N/A
Mouse Thpo-6418M Active Recombinant Mouse Thpo Protein E. coli
Mouse Thpo-111M Recombinant Mouse Thpo Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Thpo-6819M Recombinant Mouse Thpo Protein (Ser22­Thr356), N-His tagged Mammalian cells N-His Ser22­Thr356
Mouse Thpo-556MG Active GMP Recombinant Mouse Thpo protein HEK293 DNA sequence encoding NP_033405.1 was expressed with His tag at the C-terminal.
Mouse Thpo-111M-B Recombinant Mouse Thpo Protein Pre-coupled Magnetic Beads HEK293
Rat Thpo-575R Recombinant Rat Thpo protein, His & T7-tagged E.coli His/T7 Val24~Ser266 (Accession # P49745)
Rat THPO-6057R Recombinant Rat THPO Protein Mammalian Cell His
Rat THPO-5714R-B Recombinant Rat THPO Protein Pre-coupled Magnetic Beads HEK293
Rat THPO-5714R Recombinant Rat THPO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Thpo-5239R Recombinant Rat Thpo protein, GST-tagged E.coli GST 22-194 aa
Rat Thpo-891R Recombinant Rat Thpo Protein E.coli N/A
Bovine THPO-4327B Recombinant Bovine THPO Protein Yeast N/A 332aa
Cynomolgus THPO-1163C Active Recombinant Cynomolgus THPO protein, His-tagged HEK293 His Met1-Gly353
Cynomolgus Monkey THPO-2273CCL Recombinant Cynomolgus THPO cell lysate Human Cell N/A
Porcine THPO-01P GMP Recombinant Porcine THPO Protein, His-Tagged E.coli His
Zebrafish THPO-7258Z Recombinant Zebrafish THPO Mammalian Cell His
Chicken THPO-1175C Recombinant Chicken THPO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • THPO Related Articles

THPO involved in several pathways and played different roles in them. We selected most pathways THPO participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with THPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFSF14;IL6;IFNB1;CRFB4;TNFRSF11A;AMHR2;TNFRSF21;CLCF1;BMPR1AA
Jak-STAT signaling pathwayAKT2L;PIK3CG;IFNAR1;IL20RB;PIK3CB;Il23a;IL7;IFNA6;SOS1
Hematopoietic cell lineageCD34;ITGA6;Flt3l;IL4R;HLA-DRB1;Cd24a;GP9;GM2002;CR1

THPO has several biochemical functions, for example, cytokine activity, growth factor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THPO itself. We selected most functions THPO had, and list some proteins which have the same functions with THPO. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL9;C1QTNF4;SP100;Gm13290;IFNA5;GPI1;SCG2;CSF2;IL29
growth factor activityFGF6;FGF7;FGF5;FGF20;BMP2;AMBN;OGN;BMP4;MSTNB
hormone activityPRL7A1;STC1L;INHBAB;RLN3A;PRL5A1;TG;PRL8A9;IGF1;STC1

THPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THPO here. Most of them are supplied by our site. Hope this information will be useful for your research of THPO.

EP300; APH1A; NUMBL

Kuter, DJ; et al. Milestones in understanding platelet production: a historical overview. BRITISH JOURNAL OF HAEMATOLOGY 165:248-258(2014).
Arai, F; Yoshihara, H; et al. Niche Regulation of Hematopoietic Stem Cells in the Endosteum The Role of Thrombopoietin/Mp1 Signaling in the Maintenance of Quiescent Hematopoietic Stem Cells. HEMATOPOIETIC STEM CELLS VII 1176:36-46(2009).
  • Q&As
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