tph2
Share
  • Official Full Name
  • tryptophan hydroxylase 2
  • Background
  • Tryptophan Hydroxylase (TPH) belongs to the biopterin-dependent aromatic amino acid hydroxylase family. This enzyme catalyzes the first and rate limiting step in the biosynthesis of serotonin. Mutations in this gene have been implicated in a variety of di
  • Synonyms
  • TPH2; tryptophan hydroxylase 2; tryptophan 5-hydroxylase 2; FLJ37295; NTPH; tryptophan 5-monooxygenase 2; neuronal tryptophan hydroxylase; ADHD7; MGC138871; MGC138872
Cat.#:TPH2-2449HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TPH2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Tph2-455MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tph2 Protein, His/GST-tagged
+Inquiry
Cat.#:TPH2-3368HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPH2, GST-tagged
+Inquiry
Cat.#:TPH2-342HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TPH2 Protein, His-tagged
+Inquiry
Cat.#:TPH2-17253MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TPH2 Protein
+Inquiry
Cat.#:TPH2-6240RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TPH2 Protein
+Inquiry
Cat.#:TPH2-4918RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TPH2 Protein, His-tagged
+Inquiry
Cat.#:TPH2-1086CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TPH2
+Inquiry
Cat.#:TPH2-12809ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TPH2
+Inquiry
Cat.#:TPH2-699HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TPH2 lysate
+Inquiry

Involved Pathway

Tph2 involved in several pathways and played different roles in them. We selected most pathways Tph2 participated on our site, such as Amine-derived hormones, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tph2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amine-derived hormones
DBH; TPH2; DIO2; CGA; DDC
Metabolic pathways
HPSE; MTMR3; PNP6; SPHK2; MTHFD2L; CHIA; CDIPT; ACSM1; CECR1A; PNP
Metabolism
AQP1A.2; SLC5A2; CYP4F11; CYP2V1; STAB2; ACAD11; GPHNA; KCNC2; PMVK; MED20
Metabolism of amino acids and derivatives
ACMSD; CRYM; AZIN2; CKM; SLC25A15A; SLC6A8; OAZ1A; LSM1; CKMT2A; ALDH9A1A.2
Monoamine Transport
DBH; HRH3; SYN1; SCAMP2; FBXO32; TPH2; TGFB1I1; UNC13B
SIDS Susceptibility Pathways
SP3; KCNH2; RUNX3; CC2D1A; SST; LMX1B; POU2F2; KCNJ8; ASCL1; TSPYL1
Serotonergic synapse
HTR1F; PRKCB; MAOA; APP; GNG7; GNB2; CYP2D10; GNB4; HTR1E; BRAF
Serotonin Transporter Activity
TPH2; TGFB1I1; SCAMP2

Protein Function

Tph2 has several biochemical functions, for example, amino acid binding, iron ion binding, tryptophan 5-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tph2 itself. We selected most functions Tph2 had, and list some proteins which have the same functions with Tph2. You can find most of the proteins on our site.
Function
Related Protein
Function amino acid binding
Related Protein DDAH1; AARS; DPYS; TPH2; GCHFR; OTC; DDC; AARS2; DDAH2; TDO2
Function iron ion binding
Related Protein NDOR1; TPH2; FTL; CYP11C1; NOS3; CYP19A1A; CYP4V7; CYP7A1A; CYP2D9; MSMO1
Function tryptophan 5-monooxygenase activity
Related Protein TPH1A; TPH2; TPH1; TH2; TPH1B

Interacting Protein

Tph2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tph2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tph2.
YWHAE

Tph2 Related Articles

Patrick, RP; Ames, BN; et al. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB JOURNAL 28:2398-2413(2014).
Bratland, E; Magitta, NF; et al. Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity. IMMUNOBIOLOGY 218:899-909(2013).