TPP1
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Official Full Name
tripeptidyl peptidase I
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Overview
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. -
Synonyms
TPP1; tripeptidyl peptidase I; ceroid lipofuscinosis, neuronal 2, late infantile (Jansky Bielschowsky disease) , CLN2; tripeptidyl-peptidase 1; TPP I; tripeptidyl aminopeptidase; growth-inhibiting protein 1; cell growth-inhibiting gene 1 protein; lysosoma;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- His
- His (Fc)
- Avi
- His|Flag
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TPP1 Related Research Area
TPP1 involved in several pathways and played different roles in them. We selected most pathways TPP1 participated on our site, such as IRE1alpha activates chaperones, Lysosome, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IRE1alpha activates chaperones | WIPI1;FKBP14;TPP1;PDIA6;PREB;KDELR3;C19orf10;HDGF;YIF1A |
| Lysosome | GUSB;AP1S3B;AP3M2;CD68;HGSNAT;LITAF;GGA2;CLTCA;NPC2 |
| Metabolism of proteins | YKT6;SCFD1;DPH3;ZNF408;SERPINA7;SEC23IP;FKBP9;SLC25A13;GPR119 |
| Unfolded Protein Response (UPR) | TPP1;FKBP14;HYOU1;C19orf10;YY2;DNAJB9;CTDSP2;CXXC1;KDELR3 |
| XBP1(S) activates chaperone genes | TPP1;FKBP14;KLHDC3;ASNA1;SEC63;HYOU1;CXXC1;SERP1;PDIA6 |
TPP1 has several biochemical functions, for example, endopeptidase activity, metal ion binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPP1 itself. We selected most functions TPP1 had, and list some proteins which have the same functions with TPP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | SENP1;PSMB1;PSMB8F;PSMA1;CTSH;SENP5;PSMA6A;PSMA8;PSMB11 |
| metal ion binding | ZNF557;ZFP750;ELOF1;DAK;PLRDGB;TTC4;ITGAM;GDPD4;PPP1CB |
| peptidase activity | KLK1B22;OTUD4;Acr;MMP23BB;SHHA;HE1B;HM13;GM12824;PSD |
| peptide binding | ERAP2;AVPR1B;NPFFR1L2;GNRHR1;NUP98;GNRHR2;PPIA;CLTA;CMA1 |
| protein binding | KDM5B;LEF1;GRN;PSEN2;SRGAP2;POMP;LRRC8C;SYCE1;FCGR2B |
| serine-type endopeptidase activity | GZMA;GZMK;PRSS39;PRSS8;TMPRSS15;PRSS50;ST14B;IMMP2L;CFI |
| serine-type peptidase activity | F9B;ST14;GZMB;PREP;GZMK;Gzmd;PARLA;TMPRSS7;GM5077 |
| tripeptidyl-peptidase activity | TPP2;ACE;TPP1 |
TPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPP1.
cya; ubiD; gatA; q7cgu7_yerpe; fliD; q7cig0_yerpe; q7ciq5_yerpe; q7ckk4_yerpe; q81l99_bacan; yitJ; bfmbAb; q81n23_bacan; potD; argE; 15-deoxy-delta(12,14; A2M; MYC; cona_canen; HTT; CCDC88A
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several PKMYT1 inhibitors are under development and in preclinical and clinical trials for evaluating their efficacy in cancer treatment.
Yes, several clinical trials are investigating the efficacy of PKMYT1 inhibitors in various cancer types.
PKMYT1 regulates the cell cycle by inhibiting the activity of cyclin-dependent kinases (CDKs), particularly CDK1, which is crucial for G2/M phase transition.
Yes, the expression levels of PKMYT1 can be indicative of the responsiveness of cancer cells to specific treatments, making it a potential predictive biomarker.
Selective PKMYT1 inhibitors aim to minimize effects on normal cells, but potential impacts on the cell cycle of non-cancerous cells are still under investigation.
Customer Reviews (3)
Write a reviewThese resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.
The manufacturer's support is crucial for researchers using TPP1 protein in trials.
Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
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