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Txn1

  • Official Full Name

    thioredoxin 1

  • Overview

    Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes. In humans, it is encoded by the TXN gene. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin plays a central role in humans and is increasingly linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins perform a spectrum of critical functions, ranging from photosynthesis to growth, flowering and the development and germination of seeds. It has also recently been found to play a role in cell-to-cell communication.
  • Synonyms

    Txn1; ADF; Txn; Trx1; AW550880; thioredoxin 1; thioredoxin; trx; ATL-derived factor; trxA; dasC; ECK3773; fip; fipA; JW5856; tsnC;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • E.coli
  • Mouse
  • Rat
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Txn1-538M Active Recombinant Mouse Txn1, His-tagged His
Mouse Txn1-537M Active Recombinant Mouse Txn1 protein E.coli N/A Met1-Val105
Mouse Txn1-682M Recombinant Mouse Txn1 protein, His-tagged E.coli His Met1~Ala105
Mouse Txn1-6744M Recombinant Mouse Txn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Txn1-016M Recombinant Mouse Txn1 Protein E.coli
Mouse Txn1-003M Recombinant Mouse Txn1 Protein E.coli
Rat TXN1-6371R Recombinant Rat TXN1 Protein Mammalian Cell His
Rat Txn1-683R Recombinant Rat Txn1 protein, His-tagged E.coli His Met1~Ala105 (Accession # P11232)
Rat TXN1-6027R Recombinant Rat TXN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TXN1-6027R-B Recombinant Rat TXN1 Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis TRXA-0188B Recombinant Bacillus subtilis TRXA protein, His-tagged E. coli or Yeast His
E.coli trxA-2403E Recombinant E. coli trxA Protein, His-tagged E.coli His 117 AA
E.coli TRXA-1314E Recombinant Escherichia coli TRXA Protein (2-109 aa), His-tagged E.coli His 2-109 aa
E.coli trxA-005E Recombinant E. coli trxA Protein E.coli
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Txn1 involved in several pathways and played different roles in them. We selected most pathways Txn1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Detoxification of Reactive Oxygen Species, which may be useful for your reference. Also, other proteins which involved in the same pathway with Txn1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceCDKN2C;TINF2;AGO1;KAT5;IGFBP7;TERF2;TERF2IP;MOV10;EHMT2
Cellular responses to stressHSBP1A;CBX4;PTGES3;LAMTOR2;EPAS1B;MAPKAPK2B;HIF1AN;TXNRD2;DYNLL2A
Detoxification of Reactive Oxygen SpeciesPRDX3;PRDX2;TXN2;Txn1;TXN;TXNRD2
Gene ExpressionRARAA;ZNF200;LRPPRC;ZNF490;PRMT5;CCNT2A;ZNF558;ZNF549;MANEA
Generic Transcription PathwayZNF596;ZNF224;ZNF311;NR2F6B;ZNF114;ZNF333;CCNT2B;ZNF266;ZNF34
Immune SystemDEFB125;CD300LG;DEFB116;ABI1;CLEC4D;KLRB1B;IRAK3;IGHM;MYO9B
InflammasomesPANX1B;BTR22;BTR16;SUGT1;Txn1;BTR09;NLRP3;TXNIP;BTR12
Innate Immune SystemTXNIPB;DEFB4B;DEFA5;DEFB1;TREX1;BTR30;DEFA6;CFHL2;TAX1BP1B

Txn1 has several biochemical functions, for example, enzyme binding, peptide disulfide oxidoreductase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Txn1 itself. We selected most functions Txn1 had, and list some proteins which have the same functions with Txn1. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingPRKCH;PIAS1;HMGA1-RS1;CASC3;PTEN;PPP1R3B;NKX2-1;HDAC2;PLSCR4
peptide disulfide oxidoreductase activityTXN;TXNDC12;Txn1
poly(A) RNA bindingPNPT1;STRBP;LRRC59;HSPD1;FUBP1;HNRPDL;BCLAF1;NOL7;HIST1H1E
protein bindingDYM;KIF13B;NR1H2;LC3;ZMYM4;SART3;ZNF567;AHCY;MAGEB18

Txn1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Txn1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Txn1.

Ywhae; Dlg4; Pgls

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