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TTK

  • Official Full Name

    TTK protein kinase

  • Overview

    TTK (Mps1, PYT) is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines. TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centrosome
  • Synonyms

    TTK; TTK protein kinase; dual specificity protein kinase TTK; cancer/testis antigen 96; CT96; MPS1L1; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; ESK; PYT; MPS1; FLJ38280;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TTK-1503H Active Recombinant Human TTK, GST-tagged Sf9 Insect Cell GST Full length
Human TTK-748H Recombinant Human TTK Protein Kinase, GST-His Sf9 Insect Cell GST
Human TTK-12H Recombinant Human TTK protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TTK-392H Recombinant Human TTK protein, His-tagged E.coli His Gly532~Leu786
Human TTK-671HCL Recombinant Human TTK 293 Cell Lysate HEK293 N/A
Human TTK-0822H Recombinant Human TTK Protein (M1-K857, K857G), GST/Flag tagged Insect Cell GST/Flag M1-K857, K857G
Human TTK-1795HF Active Recombinant Full Length Human TTK Protein, GST-tagged Insect (sf21) GST 1-857
Human TTK-6518H Recombinant Human TTK Protein (Gly532-Ala787), N-His tagged E.coli N-His Gly532-Ala787
Human TTK-3781HFL Recombinant Full Length Human TTK protein, Flag-tagged Mamanlian cells Flag
Human TTK-0823H Recombinant Human TTK Protein (M1-K857, K857G), Flag tagged Insect Cell Flag M1-K857, K857G
Mouse Ttk-634M Recombinant Mouse Ttk Protein, His-tagged E.coli His Leu527~Thr786
Mouse Ttk-6720M Recombinant Mouse Ttk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Ttk-635R Recombinant Rat Ttk Protein, His-tagged E.coli His Glu570~Met787
Zebrafish TTK-9564Z Recombinant Zebrafish TTK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TTK Related Articles

TTK involved in several pathways and played different roles in them. We selected most pathways TTK participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleFGFR1OP;SGOL2;RBBP7;AURKB;CCND2A;YWHAE1;CTDNEP1;YWHAG;CENPJ

TTK has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TTK itself. We selected most functions TTK had, and list some proteins which have the same functions with TTK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPK11;UBA1;GPHN;CSNK1G2B;ABCC10;MYO1EB;SIK3;ERBB2;ATP2C1
protein bindingBORA;SS18;EIF3L;IPO11;ZFHX3;FAM189B;RNF4;MPPED2;BMP1A
protein serine/threonine kinase activityMAP3K14;GRK7B;PRKAA2;PIM3;TLK2;CSNK1G2A;TAOK3;MAP3K13;NEK3
protein serine/threonine/tyrosine kinase activityCLK4;DYRK3;RPS6KA2;TESK1;TESK2;AKT1;RPS6KA1;MAP2K1;MAP2K2
protein tyrosine kinase activityTNK2;BAZ1B;SHC1;MAP2K1;KIAA1804;FYN;FYNA;PDGFRB;TESK1

TTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTK here. Most of them are supplied by our site. Hope this information will be useful for your research of TTK.

N/A; TACC2; CDCA8; LRRK2; TUBB; Ttk; RPS6KA1; MAPK6; IBTK; NAA50; KIF2A; UTRN; RPL7A; SNW1; ESPL1; GEMIN5; HERC5

Aruga, A; Takeshita, N; et al. Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. CLINICAL CANCER RESEARCH 19:2224-2231(2013).
Wang, LN; Su, WJ; et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. BIOMATERIALS 33:5107-5114(2012).
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