ttk
Share
  • Official Full Name
  • TTK protein kinase
  • Background
  • TTK (Mps1, PYT) is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines. TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centrosome
  • Synonyms
  • TTK; TTK protein kinase; dual specificity protein kinase TTK; cancer/testis antigen 96; CT96; MPS1L1; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; ESK; PYT; MPS1; FLJ38280
Cat.#:Ttk-634MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ttk Protein, His-tagged
+Inquiry
Cat.#:Ttk-635RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ttk Protein, His-tagged
+Inquiry
Cat.#:TTK-12HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TTK protein, MYC/DDK-tagged
+Inquiry
Cat.#:TTK-29701THTag:
Source (Host):Species:Human
Product nameRecombinant Human TTK
+Inquiry
Cat.#:TTK-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTK protein, His-tagged
+Inquiry
Cat.#:TTK-452HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TTK, GST-tagged, Active
+Inquiry
Cat.#:TTK-748HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TTK Protein Kinase, GST-His
+Inquiry
Cat.#:TTK-9564ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TTK
+Inquiry
Cat.#:TTK-1503HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TTK (Active), GST-tagged
+Inquiry
Cat.#:TTK-671HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TTK 293 Cell Lysate
+Inquiry

Involved Pathway

TTK involved in several pathways and played different roles in them. We selected most pathways TTK participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
CSNK1D; TRP53; CEP63; CSNK2A2; SPC25; TCTN2; ATM; ORC3L; CDH1-A; PLK4

Protein Function

TTK has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TTK itself. We selected most functions TTK had, and list some proteins which have the same functions with TTK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Atp8a2; FRK; MAT2AB; GUCY2F; MST1R; CAMKVB; MYHZ1.1; GRK4; P2RY2; UCKL1A
Function protein binding
Related Protein CD79B; FLVCR1; BRSK1; FUNDC1; ICAM5; PHYH; PRLR; BICC1; RAI1; FBXO2
Function protein serine/threonine kinase activity
Related Protein DYRK4; ZAK; HIPK1; VRK2; MAP2K2A; MKNK2; SGK1; SIK2; CDK14; PLK4
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK3; AURKC; CLK4; AURKB; ACVR2B; PRKACA; CLK3; MAP2K2; AKT1; CLK1
Function protein tyrosine kinase activity
Related Protein KDR; ZAP70; MAP3K11; WEE1; BCR; FYNA; EPHA4A; TYK2; DYRK4; HCK

Interacting Protein

TTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTK here. Most of them are supplied by our site. Hope this information will be useful for your research of TTK.
N/A; TACC2; CDCA8; LRRK2; TUBB; Ttk; RPS6KA1; MAPK6; IBTK; NAA50; KIF2A; UTRN; RPL7A; SNW1; ESPL1; GEMIN5; HERC5

TTK Related Articles

Aruga, A; Takeshita, N; et al. Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. CLINICAL CANCER RESEARCH 19:2224-2231(2013).
Wang, LN; Su, WJ; et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. BIOMATERIALS 33:5107-5114(2012).