UBE2K Protein, ubiquitin-conjugating enzyme E2K

UBE2K

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UBE2K

Official Full Name ubiquitin-conjugating enzyme E2K
Background The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING;finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntingtons disease. Known functions for;this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis;in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the;endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different;isoforms have been identified for this gene.
Synonyms UBE2K; ubiquitin-conjugating enzyme E2K; HIP2, huntingtin interacting protein 2 , ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HYPG; UBC1; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2K-131H Recombinant Human UBE2K E.coli N/A
    Human UBE2K-1790H Recombinant Human Ubiquitin-Conjugating Enzyme E2K, His-tagged Human His
    Human UBE2K-208H Recombinant Human UBE2K protein E.coli N/A
    Human UBE2K-29321TH Recombinant Human UBE2K E.coli N/A
    Human UBE2K-3537H Recombinant Human UBE2K, GST-tagged E.coli GST
    Human UBE2K-4758H Recombinant Human UBE2K Protein, GST-tagged Wheat Germ GST
    Human UBE2K-571HCL Recombinant Human UBE2K 293 Cell Lysate HEK293 N/A
    Human UBE2K-649H Recombinant Human UBE2K Protein, His-tagged, Active E.coli His
    Mouse UBE2K-17722M Recombinant Mouse UBE2K Protein Mammalian Cell His
    Rhesus Macaque UBE2K-5063R Recombinant Rhesus monkey UBE2K Protein, His-tagged Mammalian Cell His
    Chicken UBE2K-3184C Recombinant Chicken UBE2K Mammalian Cell His

    UBE2K involved in several pathways and played different roles in them. We selected most pathways UBE2K participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis SIAH2L; UBE2R2; BIRC8; SAE1; FBXO2; ANAPC7; TCEB1; UBE2W; DET1; UBE2D2

    UBE2K has several biochemical functions, for example, ATP binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2K itself. We selected most functions UBE2K had, and list some proteins which have the same functions with UBE2K. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PIP5KL1; LIG4; ABL1; CKMB; MAPKAPK2; CAMK1; DNAJA3B; SMC2; CDK18; SUCLG1
    protein binding C20orf195; FAM151B; PPP1R12C; PTPRN; LNX2B; ZNF599; KRT6A; FAM192A; CHMP4C; FANCI
    ubiquitin protein ligase binding NLK; LC3; BLZF1; UBE2S; LTBR; RALB; ACTG1; UCHL1; RELA; YWHAE
    ubiquitin-protein transferase activity TRIM33; RNF13; TRAF4; RC3H2; BIRC2; CNOT4; UBE2D2; FLJ11011L; RNF6; BRCA1
    ubiquitin-ubiquitin ligase activity PPIL2; RBX1; UBE4B; UBOX5; AMFR; ANAPC11; UBE2K; PRPF19; STUB1

    UBE2K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2K here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2K.

    SIAH1; RNF138; REL; DTX3; MIPOL1; DDI1

    Rajsbaum, R; Versteeg, GA; et al. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKK epsilon Kinase-Mediated Antiviral Response. IMMUNITY 40:880-895(2014).
    Filatova, EV; Shadrina, MI; et al. Expression analysis of genes of ubiquitin-proteasome protein degradation system in MPTP-induced mice models of early stages of Parkinson's disease. DOKLADY BIOCHEMISTRY AND BIOPHYSICS 456:116-118(2014).

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