ubtf
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  • Official Full Name
  • upstream binding transcription factor, RNA polymerase I
  • Background
  • The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor, SL1. UBF binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner (1). Experiments reveal that a cooperative interaction between UBF and SL1 leads to the formation of a new protein-DNA complex at the UCE and core elements which indicate that formation of the UBF-SL1 complex is vital for transcriptional activation by UBF (2). UBF contains six HMG box domains. The contribution of each HMG box motif to its function is different (3). Its believed that HMG motifs are the DNA-binding domains of UBF. Altering one of these boxes, as in the second form of UBF, may alter the functional characteristics of the transcription factor. Thus, the existence of different forms of UBF may have important ramifications for transcription by RNA polymerase I (4).
  • Synonyms
  • UBTF; upstream binding transcription factor, RNA polymerase I; nucleolar transcription factor 1; NOR 90; UBF; autoantigen NOR-90; 90-kDa nucleolus organizer region autoantigen; UBF1; UBF-1; NOR-90
Cat.#:UBTF-2505HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBTF Protein (1-670 aa), His-SUMO-tagged
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Cat.#:UBTF-478HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human UBTF Protein, MYC/DDK-tagged
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Cat.#:UBTF-6414RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBTF Protein
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Cat.#:UBTF-1408ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBTF
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Involved Pathway

UBTF involved in several pathways and played different roles in them. We selected most pathways UBTF participated on our site, such as Gene Expression, RNA Polymerase I Chain Elongation, RNA Polymerase I Promoter Clearance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
THG1L; QTRT1; ZNF776; ZNF143; CD3EAP; ZNF460; A1CF; EIF2B1; EXOSC8; TTC6
RNA Polymerase I Chain Elongation
CBX3; TAF1A; CBX3A; EFCAB11; TAF1B; UBTF; CD3EAP; TAF1D; TAF1C
RNA Polymerase I Promoter Clearance
TAF1C; MTA2; RRN3; EHMT2; TAF1D; EFCAB11; MBD3A; CHD4; MBD3; GATAD2B
RNA Polymerase I Promoter Escape
EFCAB11; TAF1C; TAF1D; TAF1B; UBTF; CD3EAP; TAF1A; RRN3
RNA Polymerase I Promoter Opening
UBTF
RNA Polymerase I Transcription
UBTF; GATAD2AB; PTRFB; MBD3A; RRN3; MTA1; TAF1A; PTRF; EFCAB11; GATAD2B
RNA Polymerase I Transcription Initiation
MTA1; RRN3; GATAD2AB; UBTF; GATAD2B; MTA2; MBD3A; MBD3B; GATAD2A; MTA3
RNA Polymerase I Transcription Termination
UBTF; PTRFB; PTRF

Protein Function

UBTF has several biochemical functions, for example, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBTF itself. We selected most functions UBTF had, and list some proteins which have the same functions with UBTF. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein GATA3; TMPOA; SIN3B; NEUROG1; SNAI2; CRX; SSBP1; ATAD2; MSL1A; ERCC6

UBTF Related Articles

Delmani, FA; Torreblanca, J; et al. Biological activity and redistribution of nucleolar proteins of two different cell lines treated with cis-dichloro-1,2-propylenediamine-N,N,N ',N '-tetraacetato ruthenium (III) (RAP). INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 52:579-588(2014).
Yang, XY; Jin, Y; et al. Appearance of the pituitary factor Pit-1 increases chromatin remodeling at hypersensitive site III in the human GH locus. JOURNAL OF MOLECULAR ENDOCRINOLOGY 45:19-32(2010).