ucp3
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  • Official Full Name
  • uncoupling protein 3 (mitochondrial, proton carrier)
  • Background
  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This genes protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
  • Synonyms
  • UCP3; uncoupling protein 3 (mitochondrial, proton carrier); SLC25A9; mitochondrial uncoupling protein 3; solute carrier family 25 member 9;
Cat.#:UCP3-30102THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCP3, His-tagged
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Cat.#:UCP3-6423RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UCP3 Protein
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Cat.#:UCP3-5683CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UCP3
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Cat.#:UCP3-10676ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UCP3
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Cat.#:UCP3-5147HTag:N/A
Source (Host):N/ASpecies:Human
Product nameRecombinant Human Uncoupling Protein 3 (mitochondrial, proton carrier)
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Cat.#:UCP3-5149HTag:N/A
Source (Host):N/ASpecies:Human
Product nameRecombinant Human Uncoupling Protein 3 (mitochondrial, proton carrier)
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Cat.#:Ucp3-5148RTag:N/A
Source (Host):N/ASpecies:Rat
Product nameRecombinant Rat Uncoupling Protein 3 (mitochondrial, proton carrier)
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Cat.#:UCP3-524HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UCP3 293 Cell Lysate
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Involved Pathway

UCP3 involved in several pathways and played different roles in them. We selected most pathways UCP3 participated on our site, such as Diurnally regulated genes with circadian orthologs, Electron Transport Chain, Energy Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Diurnally regulated genes with circadian orthologs
NCKAP1; RBPMS; G0S2; TOB1; CRY2; NR1D2; ZFR; KLF9; QK; QKI
Electron Transport Chain
COX7A2; SCO1; COX17; COX6B1; COX6A1; SLC25A14; COX15; COX5B; UCP2; SLC25A27
Energy Metabolism
TFB2M; PPARGC1B; MEF2B; UCP3; UCP2; MYBBP1A; ESRRA; TFB1M; GABPA
Metabolism
SLC5A4; SLC5A6A; MARCKSA; ADK; LMF2; CHST14; ARSH; CD320; LBR; ECI1
Mitochondrial Uncoupling Proteins
UCP2; SLC25A14; SLC25A27; UCP3
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
TIMMDC1; ATP5L; FAM36A; SCO1; SURF1; ATP5S; SLC25A27; UCP2; NDUFAF5; SLC25A14
The citric acid (TCA) cycle and respiratory electron transport
BRP44; C2orf56; PDK4; SURF1; PDK3B; NDUFAF4; ETFA; COX16; NDUFAF3; PDP1
The fatty acid cycling model
UCP3; UCP2; SLC25A14; SLC25A27

Protein Function

UCP3 has several biochemical functions, for example, oxidative phosphorylation uncoupler activity, protein binding, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP3 itself. We selected most functions UCP3 had, and list some proteins which have the same functions with UCP3. You can find most of the proteins on our site.
Function
Related Protein
Function oxidative phosphorylation uncoupler activity
Related Protein UCP1; UCP3
Function protein binding
Related Protein C19orf57; PBX1; H2-AB1; FSTL3; CD8B; ERGIC2; TRAF3IP1; CPNE1; TYRP1; NADK
Function transporter activity
Related Protein TTPA; SLC17A9; FABP7A; SLC22A13; AP1G1; FABP9; PPIAL4A; SLC6A20B; ABCA4A; ATP5O

Interacting Protein

UCP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCP3.
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UCP3 Related Articles

Xu, HL; Hertzel, AV; et al. Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2. MOLECULAR AND CELLULAR BIOLOGY 35:1055-1065(2015).
Frisard, MI; Wu, Y; et al. Low Levels of Lipopolysaccharide Modulate Mitochondrial Oxygen Consumption in Skeletal Muscle. METABOLISM-CLINICAL AND EXPERIMENTAL 64:416-427(2015).