UGDH
-
Official Full Name
UDP-glucose 6-dehydrogenase
-
Overview
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants. -
Synonyms
UGDH; UDP-glucose 6-dehydrogenase; UDP glucose dehydrogenase; GDH; UDP Glc dehydrogenase; UDP GlcDH; UDP glucose 6 dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; UGD; UGDH_HUMAN; Uridine diphospho glucose dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
UGDH involved in several pathways and played different roles in them. We selected most pathways UGDH participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | DHDH;ALDH3A2A;UGP2;AKR1B1L;AKR1B10;UGP2B;UGT5G1;Akr1b3;AKR1B8 |
| Ascorbate and aldarate metabolism | ALDH2.2;UGT1A7C;GULO;UGT1A9;UGT1A7;UGT1A3;MIOX;ALDH2;UGT2A1 |
| Starch and sucrose metabolism | UGP2A;GPIA;GPI;GYS2;KL;UGT1A3;AGLA;Amy1;UGT1A7 |
| Amino sugar and nucleotide sugar metabolism | GPI;GFPT1;PGM1;GPI1;CYB5R3;GMPPB;GMPPA;MPI;UXS1 |
| Metabolic pathways | NADKA;QDPRB2;CSGALNACT1;LASS5;IDH2;CSAD;GRHPRB;GPAT2;ASNS |
UGDH has several biochemical functions, for example, NAD binding, UDP-glucose 6-dehydrogenase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGDH itself. We selected most functions UGDH had, and list some proteins which have the same functions with UGDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | HIBADH;GPD1C;NDUFV1;GRHPRB;GPD1L;GPD1B;DLD;HSD17B10;GAPDH |
| UDP-glucose 6-dehydrogenase activity | |
| electron carrier activity | NCF2;SDHB;ME2;GCDH;CYBA;IDO1;GLRX2;CYP19A1;LOXL2 |
UGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of UGDH.
SIRT3; UGT1A1; RAD51; ITGB1BP2; AK5; ere_dna; GRB2
- Q&As
- Reviews
Q&As (7)
Ask a questionUGDH is involved in cellular redox processes, impacting the balance of NAD+/NADH.
Alterations in UGDH can disrupt glycosaminoglycan synthesis, leading to metabolic disorders.
UGDH interacts with carbohydrate metabolism and nucleotide synthesis pathways, integrating multiple metabolic processes.
It plays a critical role in producing glycosaminoglycans, essential components of the extracellular matrix.
UGDH activity is linked to cancer, as its product, UDP-GlcUA, is vital for cell proliferation and tumor growth.
UGDH is essential in the biosynthesis of uridine diphosphate-glucuronic acid (UDP-GlcUA), a key metabolite in carbohydrate metabolism.
Modulating UGDH activity could have therapeutic potential in treating metabolic disorders and certain cancers.
Customer Reviews (3)
Write a reviewElevates the quality of our protein experiments.
Reliable data, critical for research credibility.
Enhances our understanding of protein interactions.
Ask a Question for All UGDH Products
Required fields are marked with *
My Review for All UGDH Products
Required fields are marked with *
