ugdh
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  • Official Full Name
  • UDP-glucose 6-dehydrogenase
  • Background
  • The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • UGDH; UDP-glucose 6-dehydrogenase; UDP glucose dehydrogenase; GDH; UDP Glc dehydrogenase; UDP GlcDH; UDP glucose 6 dehydrogenase; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; UGD; UGDH_HUMAN; Uridine diphospho glucose dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase
Cat.#:UGDH-30103THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGDH, His-tagged
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Cat.#:UGDH-3584HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGDH, GST-tagged
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Cat.#:UGDH-17800MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UGDH Protein
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Cat.#:UGDH-6430RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UGDH Protein
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Cat.#:UGDH-5097RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UGDH Protein, His-tagged
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Cat.#:UGDH-1953CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UGDH
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Cat.#:UGDH-6162ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UGDH
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Cat.#:UGDH-729HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UDP-glucose 6-dehydrogenase, His-tagged
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Cat.#:UGDH-516HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGDH 293 Cell Lysate
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Involved Pathway

UGDH involved in several pathways and played different roles in them. We selected most pathways UGDH participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT1A6A; KL; XYLB; AKR1B1; UGT2B15; AKR1A1A; DHDH; UGT1A9; AKR1B7; ALDH2.2
Ascorbate and aldarate metabolism
GULO; UGT1A2; UGT2B7; UGT1A6A; UGT2A1; ALDH2; ALDH9A1B; UGT1A7C; GKUP; ALDH3A2
Starch and sucrose metabolism
UGT1A2; PGM2L1; UGT2B7; UGP2; UGDH; GAA; HK1; UGP2B; AGL; AGLA
Amino sugar and nucleotide sugar metabolism
HK2; CYB5R3; FUK; GALE; CHIA; CHIA.4; GFPT1; HK1; GMPPB; GALK1
Metabolic pathways
PAFAH1B1; OGDH; GALC; CBR1; DHODH; NDUFAB1A; CYP2C50; COX6B2; PRPS1; NDUFA6

Protein Function

UGDH has several biochemical functions, for example, NAD binding, UDP-glucose 6-dehydrogenase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGDH itself. We selected most functions UGDH had, and list some proteins which have the same functions with UGDH. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein GRHPRA; IDH3A; NDUFV1; AOX1; HSD17B10; GAPDHS; GPD1B; CTBP2A; AOX3; ME3
Function UDP-glucose 6-dehydrogenase activity
Related Protein UGDH
Function electron carrier activity
Related Protein IDO1; NQO2; ACOX2; NDUFV2; ETFDH; CYP1A2; NCF1; GPX2; HSD17B6; GCDH

Interacting Protein

UGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of UGDH.
SIRT3; UGT1A1; RAD51; ITGB1BP2; AK5; ere_dna; GRB2