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  • Official Full Name
  • uridine monophosphate synthetase
  • Background
  • This gene encodes a uridine 5-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • UMPS; uridine monophosphate synthetase; uridine 5-monophosphate synthase; orotate phosphoribosyl transferase and orotidine 5 decarboxylase; OMPdecase; OPRT; OPRtase; Orotate phosphoribosyltransferase phosphoribosyltransferase; Orotidine 5 phosphate decarboxylase; UMP synthase; Uridine 5 monophosphate synthase; OTTHUMP00000215261; orotate phosphoribosyltransferase; orotidine 5-phosphate decarboxylase
Cat.#:UMPS-212HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human UMPS Protein, His-tagged
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Cat.#:UMPS-349HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human uridine monophosphate synthetase, His-tagged
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Cat.#:UMPS-3595HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UMPS, His-tagged
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Cat.#:UMPS-17837MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UMPS Protein
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Cat.#:Umps-7928MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Umps protein, His & T7-tagged
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Cat.#:UMPS-5104RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UMPS Protein, His-tagged
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Cat.#:UMPS-2918CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UMPS
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Cat.#:UMPS-10520ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UMPS
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Cat.#:UMPS-503HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UMPS 293 Cell Lysate
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Involved Pathway

UMPS involved in several pathways and played different roles in them. We selected most pathways UMPS participated on our site, such as Pyrimidine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with UMPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pyrimidine metabolism
ENTPD8; NME4; TK2; POLR1D; POLR1C; TYMS; NME1; NT5C2A; CMPK1; POLR3B
Drug metabolism - other enzymes
UCK2; UGT1A6; TYMP; UGT2B7; ITPA; NAT; UGT2A3; NAT2; GUSB; DPYD
Metabolic pathways
PANK1; PFAS; NDUFA4L; COX8A; ACOX3; PLA2G3; IVD; GAD1; IMPA2; PPAP2CB

Protein Function

UMPS has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UMPS itself. We selected most functions UMPS had, and list some proteins which have the same functions with UMPS. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein ZFP346; TERT; DROSHA; KIN; TRIM71; SRP14; RBM46; ZFML; SKIV2L; CELF3A
Function nucleic acid binding
Related Protein EWSR1A; ZNF503; CNOT4B; ZFP322A; PABPC1L; GLIS2B; FIZ1; IGF2BP2A; BLF; PPRC1
Function nucleotide binding
Related Protein MAT2AL; DPYDB; ERBB3A; NCL; CDC6; TIA1L; RPS6KA3B; ADCY1A; UBE2QL1; NAIP6
Function zinc ion binding
Related Protein SIRT5; VPS8; ADAMTS1; ZSWIM7; CAR13; APOBEC3B; CECR1; SOD1; ADAMTS7; PHC3

Interacting Protein

UMPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UMPS here. Most of them are supplied by our site. Hope this information will be useful for your research of UMPS.
CASP4; USP50; CALU; A2M; NOS3; DLST; PIK3CA; PSEN1; RPS29; RAD51; CASP8; PAXIP1; ZNF227; RB1CC1; PLA2G12A; CDC42EP3; MYH6; Kif4; Nup98; Ccdc12

UMPS Related Articles

Ciuonzo, D; De Maio, A; et al. A Systematic Framework for Composite Hypothesis Testing of Independent Bernoulli Trials. IEEE SIGNAL PROCESSING LETTERS 22:1249-1253(2015).
Tsao, N; Lee, MH; et al. The contribution of CMP kinase to the efficiency of DNA repair. CELL CYCLE 14:354-363(2015).