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  • Official Full Name
  • uracil-DNA glycosylase
  • Background
  • This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
  • Synonyms
  • UNG; uracil-DNA glycosylase; DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2;
Cat.#:UNG-1547HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human UNG protein
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Cat.#:UNG-2559HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UNG, GST tagged
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Cat.#:UNG-3600HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UNG, GST-tagged
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Cat.#:UNG-3601HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UNG protein, His-tagged
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Cat.#:UNG-17856MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UNG Protein
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Cat.#:UNG-5763CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UNG
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Cat.#:ung-1546ETag:
Source (Host):E. coliSpecies:E.coli
Product nameRecombinent E.coli ung protein
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Cat.#:ung-282ETag:His
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant E.coli uracil-DNA-glycosylase, His-tagged
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Cat.#:ung-61ETag:N/A
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant E. coli Uracil DNA Glycosylase
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Cat.#:UNG-0803BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis UNG protein, His-tagged
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Cat.#:ung-8332ETag:
Source (Host):E. coliSpecies:Rat
Product nameNative E.coli ung
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Cat.#:UNG-497HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UNG 293 Cell Lysate
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Cat.#:UNG-498HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UNG 293 Cell Lysate
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Involved Pathway

UNG involved in several pathways and played different roles in them. We selected most pathways UNG participated on our site, such as Base excision repair, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
HMGB1B; PARP4; XRCC1; POLE4; xthA; PCNA; NEIL2; nth; SMUG1; OGG1
Primary i
IL2RG; CD40; IKBKG; LCK; CD3D; AIRE; AICDA; RFXAP; CD79A; BLNK
nodeficiency
CD3D; CD8B1; BTK; RAG1; IL2RG; RFXANK; IGLL1; DCLRE1C; CD19; Cd79a, Cd79b

Protein Function

UNG has several biochemical functions, for example, damaged DNA binding, protein binding, uracil DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UNG itself. We selected most functions UNG had, and list some proteins which have the same functions with UNG. You can find most of the proteins on our site.
Function
Related Protein
Function damaged DNA binding
Related Protein REV1; XRCC1; RAD52; TRP53; XPA; RAD1; POLK; APTX; MGMT; TP53
Function protein binding
Related Protein PDCD2; TLN1; FKBP7; SLC30A3; NCBP1; MYL2; COMMD1; FGFBP1; NCOA2; ABHD1
Function uracil DNA N-glycosylase activity
Related Protein CCNO; UNG; SMUG1; TDG.1; APEX1; TDG; UNGA

Interacting Protein

UNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNG here. Most of them are supplied by our site. Hope this information will be useful for your research of UNG.
RPA2; UGI; 4505953; vpr; SEZ6L2; CAPN11; vpr; k7_vaccw; Ppp2r2d; vpr

UNG Related Articles

Pettersen, HS; Galashevskaya, A; et al. AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA REPAIR 25:60-71(2015).
White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).