uqcrc2
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  • Official Full Name
  • ubiquinol-cytochrome c reductase core protein II
  • Background
  • Ubiquinol-cytochrome c reductase core protein II is a protein that in humans is encoded by the UQCRC2 gene. Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), whi
  • Synonyms
  • UQCRC2; ubiquinol-cytochrome c reductase core protein II; cytochrome b-c1 complex subunit 2, mitochondrial; QCR2; UQCR2; mitochondrial; Complex III subunit 2; Core protein II; Cytochrome b-c1 complex subunit 2; EC 1.10.2.2; QCR2_HUMAN; Ubiquinol cytochrome c reductase complex core protein 2 mitochondrial; Ubiquinol cytochrome c reductase core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2
Cat.#:UQCRC2-3008HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquinol-Cytochrome C Reductase Core Protein II, T7-tagged
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Cat.#:UQCRC2-7158HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquinol-Cytochrome C Reductase Core Protein II, His-tagged
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Cat.#:UQCRC2-31674THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UQCRC2, T7 -tagged
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Cat.#:UQCRC2-17879MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UQCRC2 Protein
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Cat.#:UQCRC2-6458RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UQCRC2 Protein
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Cat.#:UQCRC2-5113RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UQCRC2 Protein, His-tagged
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Cat.#:UQCRC2-487HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UQCRC2 293 Cell Lysate
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Involved Pathway

UQCRC2 involved in several pathways and played different roles in them. We selected most pathways UQCRC2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRC2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
NDUFS3; ATP5S; ATP6V1A; NDUFA11; NDUFB9; ATP6V0A1B; ATP6V0A2; ATP5G3A; SDHD; COX5AA
Metabolic pathways
ALOX12B; HIBCH; FUT8; SI; PPAP2CB; LIPT1; LIPCA; SYNJ2; PDHA1; SAT1A.2
Cardiac muscle contraction
VMHCL; ATP1B3; MYH15; ATP1B2A; TNNT2A; COX6B2; CACNG6; MYL3; UQCRQ; CACNA2D1
Non-alcoholic fatty liver disease (NAFLD)
UQCRFS1; Il6ra; ERN1; PKLR; SDHA; SDHB; NDUFC2-KCTD14; NDUFB11; UQCRC2; PIK3CD
Alzheimers disease
Casp3; ATP5E; COX7B; COX6A2; ERN1; NDUFB8; CALML5; NDUFC2-KCTD14; PPP3CA; ADAM17
Parkinsons disease
ATP5D; NDUFB2; SNCAIP; NDUFC2-KCTD14; VDAC2; NDUFA5; SDHC; UBB; NDUFA13; NDUFV3
Huntingtons disease
NRF1; SLC25A5; COX7A2L; VDAC1; DCTN4; DNAH6; CREB3L2; NDUFA9; ATP5C1; TBP

Protein Function

UQCRC2 has several biochemical functions, for example, metalloendopeptidase activity, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRC2 itself. We selected most functions UQCRC2 had, and list some proteins which have the same functions with UQCRC2. You can find most of the proteins on our site.
Function
Related Protein
Function metalloendopeptidase activity
Related Protein ADAMTS7; OMA1; FAP; ADAM1B; MMP2; PAPPAB; ADAM20; ADAM5; MMP25; ADAM10
Function protein binding
Related Protein KIAA0247; ZCCHC7; UNC119; OTUD7B; CCDC167; OCRL; MCL1; MCM6; CSDC2; SOX5
Function protein complex binding
Related Protein ATP6V1B1; NR0B2; CRIPT; UQCRFS1; HCLS1; RIPK3; CPS1; WRN; RPAIN; TRADD
Function zinc ion binding
Related Protein MTA3; PHF20B; HHIP; FNTB; FBXL19; MTA2; USP13; ZBBX; EHMT1B; GCM1

Interacting Protein

UQCRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRC2.
UQCRC1; CACNA1A; a8k1f4_human; HLA-B; ARF6; 15-deoxy-delta(12,14; RNH1; ATF2; Csk; HTT; ICT1; Ddb1; Rmdn3; P; HUWE1; Ercc6l; SLX1A

UQCRC2 Related Articles

Hu, WH; Hausmann, ON; et al. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). JOURNAL OF NEUROCHEMISTRY 81:36-45(2002).