usf1
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  • Official Full Name
  • upstream transcription factor 1
  • Background
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms
  • USF1; upstream transcription factor 1; upstream stimulatory factor 1; bHLHb11; MLTFI; UEF; major late transcription factor 1; class B basic helix-loop-helix protein 11; FCHL; MLTF; FCHL1; HYPLIP1
Cat.#:USF1-1203HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Upstream Transcription Factor 1, GST-tagged
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Cat.#:USF1-1202HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Upstream Transcription Factor 1
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Cat.#:USF1-2447HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human USF1, His-tagged
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Cat.#:USF1-30031THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USF1
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Cat.#:USF1-1743CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken USF1
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Cat.#:USF1-10627ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish USF1
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Cat.#:USF1-479HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human USF1 293 Cell Lysate
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Cat.#:USF1-480HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human USF1 293 Cell Lysate
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Involved Pathway

USF1 involved in several pathways and played different roles in them. We selected most pathways USF1 participated on our site, such as Signaling mediated by p38-alpha and p38-beta, which may be useful for your reference. Also, other proteins which involved in the same pathway with USF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling mediated by p38-alpha and p38-beta
GDI1; HBP1; KRT8; USF1

Protein Function

USF1 has several biochemical functions, for example, bHLH transcription factor binding, double-stranded DNA binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USF1 itself. We selected most functions USF1 had, and list some proteins which have the same functions with USF1. You can find most of the proteins on our site.
Function
Related Protein
Function bHLH transcription factor binding
Related Protein EP300; TCF12; MAP3K10; TCF3A; USF2; SIRT1; SMAD3; BHLHE40; RUNX2; ASCL1
Function double-stranded DNA binding
Related Protein TRP63; IFI16; RAD51; MTERFD3; XRCC3; SATB1; CGGBP1; AIM2; PRKDC; EGFR
Function enzyme binding
Related Protein HIST1H2AE; GBP1; CBX1; CNTNAP2; BTG1; EGLN1; PHKG1; IQCB1; PCBP2; KPNB1
Function histone deacetylase binding
Related Protein NR2C1; YWHAB; GCM1; BRMS1LA; ZNF703; BCOR; CAMTA2; MAPK8; HDAC5; HDAC3
Function protein binding
Related Protein ATF7IP; ANKRD32; DUSP19; CALML3; SNRPD2; ZNF41; SPEG; TBC1D16; KLK6; LAPTM5
Function protein heterodimerization activity
Related Protein PPP2R1A; GCLM; NOTCH1; HIST1H2BM; HIST1H3F; TLR6; UGT1A4; CUL3; HIST1H4K; DMRT1
Function protein homodimerization activity
Related Protein TCF4; BARD1; CADM1B; CITED1; TYW5; ACTN3; Defa-rs7; UGT1A2; TBX15; TPD52
Function protein kinase binding
Related Protein NBEA; CRY1; LLGL1; ITGB1BP1; FGF19; CACNB3; ITGB2; MAPK8IP2; PLCG1; RICTOR
Function sequence-specific DNA binding
Related Protein VDRA; DBX2; ATF6B; FLI1A; ZNF323; HOXB9; HOXC6; CDX1B; NR2F1A; FOXC1B
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein MYF6; NFIX; USF2; PKNOX1; IRF8; SOX7; ATF1; JUN; MYF5; CEBPB

Interacting Protein

USF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of USF1.
PRKDC; USF2; KAT2B; PARP1; XRCC5; FOSL1

USF1 Related Articles

van Deursen, D; Jansen, H; et al. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. DIABETOLOGIA 51:2078-2087(2008).
Grassadonia, A; Tinari, N; et al. Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (mac-2BP) protein. ENDOCRINOLOGY 148:3507-3517(2007).