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USF2

Official Full Name

upstream transcription factor 2, c-fos interacting
Overview

The ubiquitously expressed cellular upstream stimulatory factor (USF) consists of 43kDa (USF-1) and 44kDa (USF-2) polypeptides which independently exhibit site-specific DNA binding and are members of the c-Myc-related family of regulatory factors containing helix-loop-helix domains. USF also contains a leucine repeat that is required for efficient DNA binding.
Synonyms

USF2; upstream transcription factor 2, c-fos interacting; upstream stimulatory factor 2; bHLHb12; FIP; FOS-interacting protein; c-fos interacting protein; major late transcription factor 2; class B basic helix-loop-helix protein 12;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	USF2-478HCL	Recombinant Human USF2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	USF2-3689H	Recombinant Human USF2 protein, GST-tagged	E.coli	GST	1-346 aa	$319 / 25ug
Human	USF2-3285H	Recombinant Human USF2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	USF2-17891M	Recombinant Mouse USF2 Protein	Mammalian Cell	His		Inquiry
Mouse	USF2-9941M	Recombinant Mouse USF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Usf2-6860M	Recombinant Mouse Usf2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	USF2-9941M-B	Recombinant Mouse USF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	USF2-6463R	Recombinant Rat USF2 Protein	Mammalian Cell	His		Inquiry
Rat	USF2-6119R	Recombinant Rat USF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	USF2-6119R-B	Recombinant Rat USF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	USF2-6595Z	Recombinant Zebrafish USF2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
USF2 Related Articles

USF2 involved in several pathways and played different roles in them. We selected most pathways USF2 participated on our site, such as Validated transcriptional targets of AP1 family members Fra1 and Fra2, which may be useful for your reference. Also, other proteins which involved in the same pathway with USF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Validated transcriptional targets of AP1 family members Fra1 and Fra2	BGLAP;MGP;CXorf15;IVL;USF2

USF2 has several biochemical functions, for example, bHLH transcription factor binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USF2 itself. We selected most functions USF2 had, and list some proteins which have the same functions with USF2. You can find most of the proteins on our site.

Function	Related Protein
bHLH transcription factor binding	HAND1;TCF4;ISL1;USF2;TCF3A;TCF3B;SOX9;IKZF4;RUNX2
protein binding	KIF1C;SH3RF1;TSKS;PYCRL;GEM;PPAP2B;SEC23A;STAMBP;MEIOB
protein heterodimerization activity	MYO5A;HIST2H2AA4;PPP1CBL;CEBPE;ATF3;CD3E;PBX1;BAXA;CAPN2
protein homodimerization activity	TCF3A;ACTN3;TCF12;ECE1;XDH;HSD17B4;RIPK2;APOBEC3G;AMBP
sequence-specific DNA binding	GATA2B;FOXO3;VRTN;ZNF187;FOXI3B;FOXD2;PPARD;DMBX1A;ERF
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	TFAP4;THRA;SOX17;IRF8;SOX9;MYF5;NFATC1;PURA;ZFHX3
transcription factor activity, sequence-specific DNA binding	ZSCAN23;SOX21;ZNF831;ETS2;ZNF83;HOXC4;HOXB4;ZSCAN4D;ZNF480

USF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USF2.

USF1; TEAD2; FOS; LZTS2; rorg_human_ebox4_dna-probe; BIRC5; HSPA4L; IGHG2

Jiang, SL; Galindo, MR; et al. Purification and identification of a transcription factor, USF-2, binding to E-box element in the promoter of human telomerase reverse transcriptase (hTERT). PROTEOMICS 10:203-211(2010).

van Deursen, D; Jansen, H; et al. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. DIABETOLOGIA 51:2078-2087(2008).