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UBE4A

  • Official Full Name

    ubiquitination factor E4A

  • Overview

    This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    UBE4A; ubiquitination factor E4A; ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitin conjugation factor E4 A; E4; KIAA0126; UBOX2; UFD2; ubiquitination factor E4A (UFD2 homolog, yeast); MGC13;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE4A-3551H Recombinant Human UBE4A, His-tagged E.coli His C-350aa
Human UBE4A-480H Recombinant Human UBE4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human UBE4A-6028H Recombinant Human UBE4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse UBE4A-17741M Recombinant Mouse UBE4A Protein Mammalian Cell His
Mouse UBE4A-9844M Recombinant Mouse UBE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ube4a-997M Recombinant Mouse Ube4a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse UBE4A-9844M-B Recombinant Mouse UBE4A Protein Pre-coupled Magnetic Beads HEK293
Rat UBE4A-6406R Recombinant Rat UBE4A Protein Mammalian Cell His
Rat UBE4A-6062R Recombinant Rat UBE4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UBE4A-6062R-B Recombinant Rat UBE4A Protein Pre-coupled Magnetic Beads HEK293
Chicken UBE4A-2599C Recombinant Chicken UBE4A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

UBE4A involved in several pathways and played different roles in them. We selected most pathways UBE4A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisSMURF1;MAP3K1;RBX1;FANCL;UBE2KA;FZR1A;UBE2L3A;FZR1;TCEB2

UBE4A has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4A itself. We selected most functions UBE4A had, and list some proteins which have the same functions with UBE4A. You can find most of the proteins on our site.

Function Related Protein
GTPase inhibitor activityRTKN;PDE6D;GPS2;IPO5;ARL2;UBE4A;CPEB2;CDC42SE1;RHOH
Roundabout bindingTGFB1I1;SLIT2;SLIT1A;SLIT3;UBE4A;SLIT1;GM4980;SLIT1B
calcium ion bindingSULF2A;SPNA2;CDH17;EFHC2;EGFL6;PCDH2G28;PCDHGB4;KCNIP4;NCALD
chemorepellent activityEFNA5;SEMA3AA;SEMA3C;UBE4A;SEMA5A;SEMA4BA;FLRT2;SEMA3D;SEMA3G
heparan sulfate proteoglycan bindingAZU1;HPSE2;Gpc2;SEMA5A;FST;GPC5A;GPC1;AGRN;GPC3
heparin bindingFGF14;CECR1;LRPAP1;BSPH1;SFRP1;CCL15;SLIT1;APOB;APOH
identical protein bindingKHDRBS1;DLC;APIP;PCNA;APPL1;DRD2;IL12B;SUN2;OMG
laminin-1 bindingDAG1;UBE4A;NTN4;NID1;SLIT2;Shh;LACRT
protein bindingSUPT4H1;KIF20B;MT1X;DOK1;LTC4S;EMP2;SP100;FAM98A;CTDSP2
protein homodimerization activityADRB2;OXA1L;BCL2A;BAX;PDGFA;TPR;SNF8;CAMK2B;CBLN1
proteoglycan bindingNID1;COL5A1;CTSB;THBS1;SLIT2;CTSK;CTSL1;CECR1A;CTSS

UBE4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4A.

MAVS; PTP4A3; UBE2D1; UBE2D3; UBE2D2; UBE2D4; CBX7

  • Q&As
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