UBA7
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Official Full Name
ubiquitin-like modifier activating enzyme 7
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Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. -
Synonyms
UBA7; ubiquitin-like modifier activating enzyme 7; UBE1L, ubiquitin activating enzyme E1 like; ubiquitin-like modifier-activating enzyme 7; D8; UBA1; ubiquitin activating enzyme E1 homolog B (yeast); UBA1B; ubiquitin activating enzyme E1; UBE2; MGC12713; UBA7_HUMAN; Ube 1L; UBE 2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; Ubiquitin-activating enzyme 7; Ubiquitin-activating enzyme E1 homolog; OTTHUMP00000212701; ubiquitin-activating enzyme-2; UBA7, ubiquitin-activating enzyme E1; UBA1, ubiquitin-activating enzyme E1 homolog B; ubiquitin; UBE1L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- His|T7
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBA7 Related Research Area
UBA7 involved in several pathways and played different roles in them. We selected most pathways UBA7 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CDC26;UBE2L3;UBE2KA;FANCL;UBA3;UBE4A;HUWE1;ITCHA;PRPF19 |
| Parkinsons disease | SLC25A6;NDUFA8;GNAI1;GNAI2;NDUFA7;NDUFC2-KCTD14;SLC6A3;NDUFA11;NDUFA2 |
UBA7 has several biochemical functions, for example, ATP binding, ISG15 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA7 itself. We selected most functions UBA7 had, and list some proteins which have the same functions with UBA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PSMC1B;ABL1;TOP2A;ZAK;SNRKA;GUK1;ATP4A;TWF1;ITPKA |
| ISG15 activating enzyme activity | |
| protein binding | INPP5B;SALL2;PDE6H;CD244;ENTPD3;FAF2;ULK1;RNF213;OSTB |
| ubiquitin activating enzyme activity | UBE1Y1;ATG7;SAE1;UBA1;UBA7;UBA6 |
| ubiquitin-protein transferase activity | PARK2;RNF213;FBXO9;CBLL1;UBE2D1;RNF217;BIRC5A;STUB1;BTR22 |
UBA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA7.
ISG15; 15-deoxy-delta(12,14; SHFM1
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